TY - JOUR T1 - Danger of bucolome in infants with hyperbilirubinaemia. Experimental evidence. JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 503 LP - 505 DO - 10.1136/adc.53.6.503 VL - 53 IS - 6 AU - R Semba AU - H Sato AU - H Yamamura Y1 - 1978/06/01 UR - http://adc.bmj.com/content/53/6/503.abstract N2 - Effects of bucolome on congenitally jaundiced Gunn rats were examined. Plasma total bilirubin level fell immediately after a single injection of bucolome and the lowered level persisted for more than 6 hours. Plasma unbound-bilirubin level and cerebellar bilirubin content increased simultaneously with the drop in total plasma bilirubin level. Kernicterus was observed in the brains of the treated rats 6 hours after the treatment. LD50 of the drug in jaundiced rats was about 37 mg/kg, about one-tenth of the value in nonjaundiced rats. It is suggested that bucolome displaces bilirubin from albumin, transferring bilirubin from blood into tissues including the brain, and resulting in kernicterus. The use of bucolome in infants with hyperbilirubinaemia is inadvisable. ER -