RT Journal Article
SR Electronic
T1 Renin and aldosterone response in human newborns to acute change in blood volume.
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 461
OP 467
DO 10.1136/adc.53.6.461
VO 53
IS 6
A1 M J Dillon
A1 K B Rajani
A1 V Shah
A1 J M Ryness
A1 R D Milner
YR 1978
UL http://adc.bmj.com/content/53/6/461.abstract
AB Increased activity of the renin/aldosterone system in the neonatal period is now well established in both animals and man but the control mechanisms are poorly understood. We have monitored the plasma renin activity (PRA) and plasma aldosterone concentration (PAldo) in 14 infants undergoing 21 exchange transfusions. PRA and PAldo were measured before and at 5, 10, 15, 30, 45, and 60 minutes after the injection, and 5, 10, 15, and 30 minutes after the withdrawal of 7 ml blood/kg birthweight immediately before exchange transfusions. PRA increased to a maximum of 53% and decreased to a maximum of 39% of the resting values after withdrawal or injection of blood respectively. PAldo values did not change significantly during the same period. Thus the renin-angiotensin system in the newborn infant is responsive to changes in blood volume.