RT Journal Article SR Electronic T1 Accidental intra-arterial injection. JF Archives of Disease in Childhood JO Arch Dis Child FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP 396 OP 400 DO 10.1136/adc.53.5.396 VO 53 IS 5 A1 Wynne, J M A1 Williams, G L A1 Ellman, B A YR 1978 UL http://adc.bmj.com/content/53/5/396.abstract AB Accidental intra-arterial injection of intramuscular antibiotic preparations is described in 3 cases in infants. In 2 benzathine penicillin was injected, and in 1 rolitetracycline. The clinical features are dominated by arteriolar obstruction which produces gangrene of the most severely affected limb. In addition, neuroloigcal involvement occurs when vessels to nerves or spinal cord are involved. The arteriolateral aspect of the thigh is preferable to the buttock as a site for intramuscular injection, and a short (2.5 cm) needle should be used to minimise the risk of intra-arterial injection.