PT - JOURNAL ARTICLE AU - Wynne, J M AU - Williams, G L AU - Ellman, B A TI - Accidental intra-arterial injection. AID - 10.1136/adc.53.5.396 DP - 1978 May 01 TA - Archives of Disease in Childhood PG - 396--400 VI - 53 IP - 5 4099 - http://adc.bmj.com/content/53/5/396.short 4100 - http://adc.bmj.com/content/53/5/396.full SO - Arch Dis Child1978 May 01; 53 AB - Accidental intra-arterial injection of intramuscular antibiotic preparations is described in 3 cases in infants. In 2 benzathine penicillin was injected, and in 1 rolitetracycline. The clinical features are dominated by arteriolar obstruction which produces gangrene of the most severely affected limb. In addition, neuroloigcal involvement occurs when vessels to nerves or spinal cord are involved. The arteriolateral aspect of the thigh is preferable to the buttock as a site for intramuscular injection, and a short (2.5 cm) needle should be used to minimise the risk of intra-arterial injection.