RT Journal Article
SR Electronic
T1 Arthrogryposis multiplex congenita. Search for prenatal factors in 66 sporadic cases.
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 618
OP 623
DO 10.1136/adc.51.8.618
VO 51
IS 8
A1 R Wynne-Davies
A1 G C Lloyd-Roberts
YR 1976
UL http://adc.bmj.com/content/51/8/618.abstract
AB In a family and epidemiological survey of 66 cases of arthrogryposis multiplex congenita all cases were found to be sporadic and no family association with clubfoot, congenital dislocation of the hip, or hereditary neuromuscular disease was found. The mothers were significantly older than average. Oligohydramnios was noted in only one-third of cases but many other complications of pregnancy, including probable attempts at abortion, had occurred. It is likely that most cases of arthrogryposis are nongenetic and result from a defective intrauterine environment, whether hormonal, vascular, mechanical, or possibly infective.