TY - JOUR T1 - Arthrogryposis multiplex congenita. Search for prenatal factors in 66 sporadic cases. JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 618 LP - 623 DO - 10.1136/adc.51.8.618 VL - 51 IS - 8 AU - R Wynne-Davies AU - G C Lloyd-Roberts Y1 - 1976/08/01 UR - http://adc.bmj.com/content/51/8/618.abstract N2 - In a family and epidemiological survey of 66 cases of arthrogryposis multiplex congenita all cases were found to be sporadic and no family association with clubfoot, congenital dislocation of the hip, or hereditary neuromuscular disease was found. The mothers were significantly older than average. Oligohydramnios was noted in only one-third of cases but many other complications of pregnancy, including probable attempts at abortion, had occurred. It is likely that most cases of arthrogryposis are nongenetic and result from a defective intrauterine environment, whether hormonal, vascular, mechanical, or possibly infective. ER -