RT Journal Article
SR Electronic
T1 Association of cystic fibrosis with allergy.
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 507
OP 511
DO 10.1136/adc.51.7.507
VO 51
IS 7
A1 J O Warner
A1 B W Taylor
A1 A P Norman
A1 J F Soothill
YR 1976
UL http://adc.bmj.com/content/51/7/507.abstract
AB Immediate skin hypersensitivity to various inhalant allergens was present in 59% of 123 children with cystic fibrosis (CF), a much higher percentage than in the general population. This is consistent with the idea that atopy arises as a result of impaired handling of antigen at mucosal surfaces. The allergic CF children had more chest infections, a worse chest x-ray appearance, and lower peak expiratory flow rates. Allergic diseases were also frequent in the CF obligate heterozygotes (32% of mothers and 26% of fathers). It is suggested that the heterozygotes may also have a mucosal abnormality resulting in defective antigen handling.