RT Journal Article
SR Electronic
T1 Renal loss of folate in the newborn infant
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 292
OP 296
DO 10.1136/adc.49.4.292
VO 49
IS 4
A1 M. J. Landon
A1 E. N. Hey
YR 1974
UL http://adc.bmj.com/content/49/4/292.abstract
AB Renal excretion of folate during the first 5 days of life has been measured in 10 infants of 31 to 40 weeks' gestation and compared with inulin clearance. Average daily folate loss per unit surface area (23 μg/m2) was nearly 8 times as high as in adult life and more than enough to account for the observed fall in plasma folate activity. No difference was detected between the pattern of folate excretion in preterm and term infants. Poor tubular reabsorption of filtered folate is thought to be responsible for the loss observed.