PT  - JOURNAL ARTICLE
AU  - D N Challacombe
AU  - S Edkins
AU  - G A Brown
TI  - Duodenal bile acids in infancy.
AID  - 10.1136/adc.50.11.837
DP  - 1975 Nov 01
TA  - Archives of Disease in Childhood
PG  - 837--843
VI  - 50
IP  - 11
4099  - http://adc.bmj.com/content/50/11/837.short
4100  - http://adc.bmj.com/content/50/11/837.full
SO  - Arch Dis Child1975 Nov 01; 50
AB  - Duodenal bile acids have been estimated in three age groups in infancy from birth to 7 months, and age-related changes have been shown. The lowest concentrations of duodenal bile acids occurred in the youngest infants, and increasing concentrations were found with increasing age. Taurine conjugated bile acids predominated in early infancy, while in older infants bile acids were mainly conjugated with glycine. The probable presence of taurolithocholic acid in the duodenal bil of 2 newborns before the establishment of a gastrointestinal microflora remains to be confirmed, but could result either from transplacental passage of secondary bile acids or from endogenous synthesis by the fetal liver.