TY - JOUR T1 - Insulin response to intravenous glucagon in children with familial constitutional short stature. JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 805 LP - 808 DO - 10.1136/adc.50.10.805 VL - 50 IS - 10 AU - M Karp AU - Z Laron AU - M Doron Y1 - 1975/10/01 UR - http://adc.bmj.com/content/50/10/805.abstract N2 - An intravenous glucagon test was performed in 8 children with familial constitutional short stature who were also lean. These children were randomly selected from a larger group of children with the same clinical manifestation and who had been shown to have a low insulin response to an oral glucose tolerance test and to an intravenous arginine test, without glucose intolerance. 7 out of 8 children showed a normal insulin response to intravenous glucagon, with a peak level of 53--180 millimicron/ml 2 minutes after the injection. It is assumed that these insulin responses represent an intact 'rapid' pool of insulin within the beta-cell, and can explain the absence of glucose intolerance in all the children so far studied. ER -