RT Journal Article SR Electronic T1 Failure of massive single oral dose of vitamin A to prevent deficiency JF Archives of Disease in Childhood JO Arch Dis Child FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP 525 OP 527 DO 10.1136/adc.46.248.525 VO 46 IS 248 A1 Pereira, Sheila M. A1 Begum, Almas YR 1971 UL http://adc.bmj.com/content/46/248/525.abstract AB Preschool children maintained on low and moderate carotene diets were given a single oral dose of 50,000 μg vitamin A palmitate. On the low carotene diet, xerosis was observed in 8 weeks' time in the control group of children, and in 10 weeks' time in the children given the load of vitamin A. Statistical differences in serum vitamin A values between the groups were not of significance after 18 weeks. Children on a moderate carotene diet did not benefit from the loading dose of vitamin A.