TY - JOUR T1 - Effects of Corticosteroids on Distribution of Histamine in the Blood of Asthmatic Children JF - Archives of Disease in Childhood JO - Arch Dis Child SP - 54 LP - 58 DO - 10.1136/adc.45.239.54 VL - 45 IS - 239 AU - J. F. Porter AU - J. A. Young AU - R. G. Mitchell Y1 - 1970/02/01 UR - http://adc.bmj.com/content/45/239/54.abstract N2 - Blood and plasma histamine levels, together with circulating basophil and eosinophil counts, were estimated in a group of asthmatic children. Short-term studies were carried out on 7 patients, each of whom was given a single dose of corticosteroid, and the effects of the hormone were monitored for periods of up to two hours. Usually a fall occurred in the whole blood histamine level, basophil count, and eosinophil count, but no change occurred in the plasma histamine level, which remained very low throughout. In 3 cases, follow-up studies showed that in 2 cases out of 3, whole blood histamine levels were lower during treatment with corticosteroids, than when steroids were not being given. ER -