We agree that sirolimus may help children with Congenital
Hyperinsulinism who do not respond to diazoxide or octreotide. Sirolimus
is, however, unlicensed, with little long term experience, and the
mechanism by which it reduces hypoglycaemia remains speculative. As
sirolimus is an immunosuppressant, its use in young infants has to be
carefully monitored in specialist centres under strict protocols. We are,
therefore, re...
We agree that sirolimus may help children with Congenital
Hyperinsulinism who do not respond to diazoxide or octreotide. Sirolimus
is, however, unlicensed, with little long term experience, and the
mechanism by which it reduces hypoglycaemia remains speculative. As
sirolimus is an immunosuppressant, its use in young infants has to be
carefully monitored in specialist centres under strict protocols. We are,
therefore, reluctant to advocate the routine use of sirolimus in
Congenital Hyperinsulinism until more evidence has accumulated.
Khan et al. make a strong case for investment in point-of-care
lactate testing in low and middle income countries (LMICs) (1). They
believe that this would identify children at high risk of death, and would
save lives because these children could receive earlier resuscitation.
Unfortunately the optimal management of children with hyperlactataemia in
LMICs is far from clear. Although Khan et al. extrapolate from findings i...
Khan et al. make a strong case for investment in point-of-care
lactate testing in low and middle income countries (LMICs) (1). They
believe that this would identify children at high risk of death, and would
save lives because these children could receive earlier resuscitation.
Unfortunately the optimal management of children with hyperlactataemia in
LMICs is far from clear. Although Khan et al. extrapolate from findings in
well-resourced settings to suggest that early fluid resuscitation would be
beneficial, this is contrary to the findings of the FEAST study in which
bolus fluid resuscitation in African children with signs of shock produced
an increase in mortality (2). Of note, this effect was also observed in
the subgroup of children with hyperlactataemia.
Not only is hyperlactataemia a consequence of sepsis, but it is also
a defining feature of severe malaria which is a common cause of death in
many LMICs (3). Unlike the situation in sepsis, the pathophysiology of
hyperlactataemia in malaria is thought to involve microvascular
obstruction by parasitized red blood cells, microvascular dysfunction, and
anaemia (4,5). Aggressive fluid resuscitation is discouraged in severe
malaria, and detailed physiological studies in adults with severe malaria
showed that fluid resuscitation failed to reduce microvascular obstruction
and lactate concentrations (5). However, when hyperlactataemia is
associated with severe malarial anaemia, blood transfusion can be
lifesaving (3).
It is likely that point of care lactate testing in LMICs would
achieve the goal of identifying children at higher risk of death, but it
is far from certain whether this would be accompanied by the improved
outcomes that would be needed to justify the investment. Amongst children
with malaria it may identify the need for parenteral artesunate or blood
transfusion, but in children with sepsis further research is needed to
define the optimal management strategies when intensive care is limited or
unavailable.
1. Khan M, Brown N, Mian AI. Point-of-care lactate measurement in
resource-poor settings. Arch Dis Child 2016;101(4):297-8.
2. Maitland K, Kiguli S, Opoka RO, et al. Mortality after fluid bolus in
African children with severe infection. N Engl J Med 2011;364(26):2483-95.
3. World Health Organization. Guidelines for the treatment of malaria.
Third edition, 2015.
4. Miller LH, Ackerman HC, Su XZ, et al. Malaria biology and disease
pathogenesis: insights for new treatments. Nature medicine 2013;19(2):156-
67.
5. Hanson JP, Lam SW, Mohanty S, et al. Fluid resuscitation of adults with
severe falciparum malaria: effects on Acid-base status, renal function,
and extravascular lung water. Crit Care Med 2013;41(4):972-81.
Safety netting in the Emergency Department (ED) is key to the
practice of safe medicine. Following the article by de Vos-Kerkhof (1),
we present further evidence to suggest that there is a lack of
standardised safety netting. In addition, we found a disparity between
paediatric trainees' perception of their safety netting practice and what
they actually documented in the medical notes.
Safety netting in the Emergency Department (ED) is key to the
practice of safe medicine. Following the article by de Vos-Kerkhof (1),
we present further evidence to suggest that there is a lack of
standardised safety netting. In addition, we found a disparity between
paediatric trainees' perception of their safety netting practice and what
they actually documented in the medical notes.
In a retrospective case notes review of 100 consecutive ED
attendances to our hospital seen by the paediatric team and discharged
from ED, only 16% had documentation that the families had been told about
the existence of uncertainty around the diagnosis and the course of the
illness. This compares unfavourably with the fact that 73% of surveyed
paediatric trainees reported that they routinely mentioned this to
families. Furthermore, the signs and symptoms to look for had only been
documented in 27% of cases, though 88% of trainees reported discussing
this with the family. 39% of the notes reviewed had no specific safety
netting documentation of any kind.
It is clear that for non-consultant paediatricians, who are the
clinicians seeing most referred children in ED, a gap exists between the
safety netting that they report undertaking and what is documented. This
may be in part because they provided verbal safety netting advice without
documenting it but it also suggests that safety netting procedures are
poor, despite the clinical and medico-legal imperative for adequate safety
netting and documentation advocated by the National Institute for Health
and Care Excellence(2).
Clearly training for junior doctors on safety netting and its
documentation needs to improve. A safety netting checklist and more high
quality patient information leaflets may help clinicians to offer adequate
advice and information to families at the time of discharge.
(297 words)
1. de Vos-Kerkhof E, Geurts DH, Wiggers M, Moll HA and Oostenbrink R.
Tools for 'safety netting' in common paediatric illnesses: a systematic
review in emergency care. Archives of Disease in Childhood. 2016; 101: 131
-9.
2. Fields E, Chard J, Murphy MS and Richardson M. Assessment and
initial management of feverish illness in children younger than 5 years:
summary of updated NICE guidance. BMJ (Clinical Research Ed). 2013; 346:
f2866.
My child also has CSID. She is about to be 8 yrs old and has been on
Sucraid for the last 6-7 yrs. I am looking for an alternative to this
medication as sometimes we cannot get the medication and have to go a
strict diet until we can get some again. I will look into this alternative
and post results later.
Maria A Quigley1, Claire Carson1, Julia Morinis1,2,3.
1 National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK
2 Department of Paediatric Medicine, Hospital for Sick Children, Toronto,
Ontario, Canada
3 Centre for Research on Inner City Health, The Keenan Research Centre, Li
Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario,
Canada
Maria A Quigley1, Claire Carson1, Julia Morinis1,2,3.
1 National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK
2 Department of Paediatric Medicine, Hospital for Sick Children, Toronto,
Ontario, Canada
3 Centre for Research on Inner City Health, The Keenan Research Centre, Li
Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario,
Canada
We would like to thank Michael A Colvin for highlighting the
distinction between the presence of the child's biological father in the
household and the presence of the mother's partner in the household. As
Dr Colvin points out, the data in Table 1 of our paper suggest that 14% of
five year old children in the study do not have their father living in
their home and, among the children of teenage mothers, this proportion is
53.5%. We thank Dr Colvin for highlighting this as this variable is
labelled incorrectly in Table 1 of our paper and it should read as
'Partner in the home at 5 years' (i.e. this would not necessarily be the
child's father) rather than 'Father in the home at 5 years'. We have also
looked at the effects on child cognitive ability of having the biological
father resident in the family home, both at the first survey (9 months)
and at the five-year follow-up. Overall, 73% of children had their father
resident at both surveys and 12.5% had their father leave by the time of
the five year survey; in the families with teenage mothers, these
proportions were 21.4% and 24.8% respectively. In addition, compared with
children whose fathers were in the home at both surveys, there was a
statistically significantly lower BAS Naming Vocabulary score in children
whose fathers had left during the study (-3.8), or who were not living in
the home at either survey (-7.2). In the small number of children whose
fathers were not there at baseline, but had returned to the family home
during the study, there was also an adverse effect on BAS Naming
Vocabulary score (-4.9), hence suggesting a negative impact of family
instability, as has been found in other studies, including the Millennium
Cohort Study. However, after adjusting for the other variables in our
models, the effect of family instability was not statistically significant
and did not alter our coefficients for mother's age (data available on
request). For example, model E from Table 2 of our paper shows a
statistically significantly lower BAS Naming Vocabulary score in children
of teenage mothers compared with children of mothers aged 25-34 (-3.8, 95%
CI: -6.3 to -1.3). When we replaced 'marital status' (which does not
distinguish between father and partner, or change of partner) in this
model with 'family instability' (as measured by the natural father's
residence in the child's home at both surveys) the effect of teenage
motherhood was very similar (-3.9, 95% CI -6.4 to -1.5). Hence, we
believe that the conclusions drawn from our study are robust.
This is a timely and important article. Pretermitting whether
parental consent can ever be valid for non-therapeutic surgeries on
minors, certainly Mr. Wheeler is correct that at the very least the
permission of both parents should be necessary for the circumcision of a
male child. Too often here in the U.S. the matter ends up in court. I
have been involved in one way or another in seven such cases in t...
This is a timely and important article. Pretermitting whether
parental consent can ever be valid for non-therapeutic surgeries on
minors, certainly Mr. Wheeler is correct that at the very least the
permission of both parents should be necessary for the circumcision of a
male child. Too often here in the U.S. the matter ends up in court. I
have been involved in one way or another in seven such cases in the last
ten years. Quite often the matter is one of spite, although occasionally
religion is involved. One such important case is presently wending its
way through the Oregon courts. The child is invariably placed in the
middle, where he does not belong. The real solution is statutory.
Parliament (and in the U.S., Congress or the state legislatures) should
pass legislation requiring the consent of both parents (unless the
parental rights of one parent have been entirely forfeited) for the non-
therapeutic circumcision of male minors, whether the circumcision be
secular or religious. (In cases of divorce where one parent has custody
but the other parent might obtain custody automatically upon the death of
the custodial parent, the consent of both parents should be required).
However, regardless of the statutory or common law, basic ethics require
that the surgeon ascertain the wishes of both parents and refrain from
circumcising a boy if either parent, or the boy himself, objects.
It would be useful to ascertain whether or not the "new"
sphygmanometer being compared with the Omron HEM 711(1) was an aneroid
device, given the fact that those of us who lamented what we perceived to
be an ill advised rejection of the mercury device welcomed the prospect
that aneriod sphygmanometers "may replace the traditional mercury column
in the healthcare workplace"(2). In the latter study, there were no
signific...
It would be useful to ascertain whether or not the "new"
sphygmanometer being compared with the Omron HEM 711(1) was an aneroid
device, given the fact that those of us who lamented what we perceived to
be an ill advised rejection of the mercury device welcomed the prospect
that aneriod sphygmanometers "may replace the traditional mercury column
in the healthcare workplace"(2). In the latter study, there were no
significant differences(using the paired t-test) between the mercury
standard and the aneroid device(Baum & Co), but the oscillometric
device(Omron HEM-907)significantly(p=0.002) overestimated the systolic
blood pressure(SBP) and significantly(p=0.0002) underestimated the
diastolic blood pressure(DBP)(2). A later study study compared the Welch
Allyn Tycos 767-Series Mobile aneroid sphygmanometer with the mercury
device, and found no statistically significant difference for SBP but a
significantly(p < 0.0001) lower reading for DBP using the aneroid
device(3). Oscillometric devices, on the other hand, have proved to be
almost universally unreliable. In one study, an evaluation of 9 devices
showed that "accuracy appeared to deccrease at increasing blood pressure
levels" with the potential consequence that "in treated hypertensive
patients the necessary adaptation of treatment will not take place"(4).
More recently, a comparison was made between the professional
oscillometric device BpTRU, that had achieved an A grade of the British
Hypertension Society validation protocol for both SBP and DBP measurement,
and the standard mercury sphygmanometer(Baumanometer; WA Baum Co). A total
of 5070 BP measurements were made using the two devices simultaneously.
Unreliable readings(ie > 10 mm Hg difference in either SBP or DBP) were
found in 755 patients. Unreliable readings occured in 15% of systolic and
6.4% of diastolic blood pressures(5). In view of the fact that "A
decreasing arm circumference was a significant predictor of persistent
UOBP(unreliable oscillometric BP)"(5), this observation might signify that
oscillometric devices might be inherently unreliable in children
References
(1) Midgley PC., Wardhaugh B., Macfarlane C., Magowan R., Kelnar CJH
Blood pressure in children 4-8 years: comparison of Omron HEM 711 and
sphygmanometer blood pressure measurements
Arch Dis Child 2009;94:955-8
(2)Elliot WJ., Young PE., DeVivo L., Feldstein J., Black HR
A comparison of two sphygmanometers that may replace the traditional
mercury column in the healthcare workplace
Blood Pressure Monit 2007;12:23-8
(3) Ma Y., Temprosa M., Fowler S et al
Evaluating the accuracy of an aneroid sphygmanometer in a clinical trial
setting
Am J Hypertens 2009;22:263-6
(4) Braam RL., Thien T
Is the accuracy of blood pressure measuring devices underestimated at
increasing blood pressure levels?
Blood Pressure Monitoring 2005;10:183-9
(5)Stergiou GS., Lourida p., Tzamouranis D., Baibas NM
Unreliable oscillometric blood pressure measurement;prvalence,
repeatability and characteristics of the phenomenon
J Human Hypertension 2009;23:794-800
We read with interest Marko Kerac's excellent article on wasting
amongst under 6-month old infants in developing countries (1). There is
a considerable amount of excellent research on how to identify
malnutrition. We also have comprehensive, effective, evidence on how to
manage malnutrition and reduce mortality (2). However, we and others have
audited the identification of malnutrition in children...
We read with interest Marko Kerac's excellent article on wasting
amongst under 6-month old infants in developing countries (1). There is
a considerable amount of excellent research on how to identify
malnutrition. We also have comprehensive, effective, evidence on how to
manage malnutrition and reduce mortality (2). However, we and others have
audited the identification of malnutrition in children admitted to
hospital and found that it is often unrecognized and so the appropriate
management is not instituted. Unfortunately there is a paucity of good
quality research on why many health professionals in developing countries
fail to identify malnutrition in hospitalized children and even if they do
why they are not instigating the published and widely disseminated
guidelines. Failure to recognize malnutrition can have catastrophic
consequences, as mortality rates can be reduced from as high as 50% to 5%
by simply using the WHO "10-step" guidance (2).
Our audit and literature review suggested potential barriers to the
identification of malnutrition included: that the focus of attention was
an infective illness or other co-morbidities, low staff to patient ratio,
lack of supplies, poor health care infrastructures (leading to poor
conditions on wards), inadequate or non-existent undergraduate and in-
service training and a lack of successful dynamics within the work-force.
With malnutrition contributing to 53% of child deaths (3), it is
imperative that we address the failure to identify malnutrition and the
implementation of management guidelines.
References
1. Kerac, M., Blencowe, H., Grijalva-Eternod, C., McGrath, M.,
Shoham, J., Cole, T., Seal, T. Prevalence of wasting among under 6-month-
old infants in developing countries and implications of new case
definitions using WHO growth standards: a secondary data analysis,
Archives of diseases in childhood. 2011 ;96:1008-1013 Published Online
First: 2 February 2011 doi:10.1136/adc.2010.191882
2. WHO. Guidelines for the in-patient treatment of severely
malnourished children, 2003.
3. Caulfield, L.E., de Onis, M., Bl?ssner, M., Black, R.E.
Undernutrition as an underlying cause of child deaths associated with
diarrhea, pneumonia, malaria, and measles. The American Journal of
Clinical Nutrition. 2004 July 1, 2004;80(1):193-8.
Leven and Mcdonald (1) report on the common occurrence of neonatal
hypernatremic dehydration in breastfed infants and how early weighting is
an effective means of detecting this condition. Studies of this type are
the “tip of the iceberg” of much bigger problem, that of insufficient
lactation in primiparous women. It is well recognized that primiparous
woman produce less milk than multiparous and that 16% of exclusivel...
Leven and Mcdonald (1) report on the common occurrence of neonatal
hypernatremic dehydration in breastfed infants and how early weighting is
an effective means of detecting this condition. Studies of this type are
the “tip of the iceberg” of much bigger problem, that of insufficient
lactation in primiparous women. It is well recognized that primiparous
woman produce less milk than multiparous and that 16% of exclusively
breastfed infants of primiparous women have > 10% weight loss.(2, 3)
Neonatal hypernatremic dehydration is difficult to recognize on clinical
grounds and can easily be confused for neonatal sepsis.(4) Insufficient
lactation and excessive weight loss should be an anticipated problem.
Excessive weight loss and hypernatremic dehydration is largely preventable
by the judicious use of supplement infant formula or expressed breast
milk.
A simple and effective way of preventing neonatal dehydration is to
have breastfeeding mothers use a supplemental nursing system until
successful lactation is established. This system is used with great
success by lactation consultants, yet most physicians, maternity wards and
breastfeeding mothers are unaware that this system exists. A supplemental
nursing system consists of a container which delivers supplemental milk
via a capillary tube that is taped to the mother’s nipple. The flow rate
of supplemental milk through the capillary tube can be adjusted.
Supplemental milk is delivered while the infant is nursing from the
mother’s breast, therefore the mother’s milk supply is stimulated and the
child continues to receive breast milk. The supplemental milk can be
discontinued once the milk supply has come in and successful lactation has
been established. The wider use of this system in the first few days of
life until successful lactation is established would greatly reduce the
incidence of both neonatal hypernatremic dehydration and breastfeeding
jaundice. While early detection of excessive weight loss is important,
the ultimate goal is prevention.
1. Leven LV, Macdonald PD. Reducing the incidence of neonatal
hypernatraemic dehydration. Arch Dis Child 2008;93:811.
2. Ingram J, Woolridge M, Greenwood R. Breastfeeding: it is worth
trying with the second baby. Lancet 2001;358:986-7.
3. Dewey KG, Nommsen-Rivers LA, Heinig MJ, Cohen RJ. Risk factors for
suboptimal infant breastfeeding behavior, delayed onset of lactation, and
excess neonatal weight loss. Pediatrics 2003;112:607-19.
4. Moritz ML, Manole MD, Bogen DL, Ayus JC. Breastfeeding-associated
hypernatremia: are we missing the diagnosis? Pediatrics 2005;116:e343-7.
We thank Professor Hall for drawing our attention to this issue. At
present there are no relevant published recommendations in the UK but we
would agree that both vaccination against VZV and influenza should be
offered and recommended to children receiving long term aspirin.
We agree that sirolimus may help children with Congenital Hyperinsulinism who do not respond to diazoxide or octreotide. Sirolimus is, however, unlicensed, with little long term experience, and the mechanism by which it reduces hypoglycaemia remains speculative. As sirolimus is an immunosuppressant, its use in young infants has to be carefully monitored in specialist centres under strict protocols. We are, therefore, re...
Khan et al. make a strong case for investment in point-of-care lactate testing in low and middle income countries (LMICs) (1). They believe that this would identify children at high risk of death, and would save lives because these children could receive earlier resuscitation. Unfortunately the optimal management of children with hyperlactataemia in LMICs is far from clear. Although Khan et al. extrapolate from findings i...
Safety netting in the Emergency Department (ED) is key to the practice of safe medicine. Following the article by de Vos-Kerkhof (1), we present further evidence to suggest that there is a lack of standardised safety netting. In addition, we found a disparity between paediatric trainees' perception of their safety netting practice and what they actually documented in the medical notes.
In a retrospective case...
My child also has CSID. She is about to be 8 yrs old and has been on Sucraid for the last 6-7 yrs. I am looking for an alternative to this medication as sometimes we cannot get the medication and have to go a strict diet until we can get some again. I will look into this alternative and post results later.
Conflict of Interest:
None declared
Maria A Quigley1, Claire Carson1, Julia Morinis1,2,3.
1 National Perinatal Epidemiology Unit, University of Oxford, Oxford, UK
2 Department of Paediatric Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
3 Centre for Research on Inner City Health, The Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada
We would like to...
Sirs:
This is a timely and important article. Pretermitting whether parental consent can ever be valid for non-therapeutic surgeries on minors, certainly Mr. Wheeler is correct that at the very least the permission of both parents should be necessary for the circumcision of a male child. Too often here in the U.S. the matter ends up in court. I have been involved in one way or another in seven such cases in t...
It would be useful to ascertain whether or not the "new" sphygmanometer being compared with the Omron HEM 711(1) was an aneroid device, given the fact that those of us who lamented what we perceived to be an ill advised rejection of the mercury device welcomed the prospect that aneriod sphygmanometers "may replace the traditional mercury column in the healthcare workplace"(2). In the latter study, there were no signific...
Dear Sir:
We read with interest Marko Kerac's excellent article on wasting amongst under 6-month old infants in developing countries (1). There is a considerable amount of excellent research on how to identify malnutrition. We also have comprehensive, effective, evidence on how to manage malnutrition and reduce mortality (2). However, we and others have audited the identification of malnutrition in children...
Leven and Mcdonald (1) report on the common occurrence of neonatal hypernatremic dehydration in breastfed infants and how early weighting is an effective means of detecting this condition. Studies of this type are the “tip of the iceberg” of much bigger problem, that of insufficient lactation in primiparous women. It is well recognized that primiparous woman produce less milk than multiparous and that 16% of exclusivel...
We thank Professor Hall for drawing our attention to this issue. At present there are no relevant published recommendations in the UK but we would agree that both vaccination against VZV and influenza should be offered and recommended to children receiving long term aspirin.
Conflict of Interest:
None declared
Pages