492 e-Letters

published between 2005 and 2008

  • Interaction between high-sensitivity C reactive protein levels and magnesium levels in the children
    Ahmet Sert

    We read with interest the article by Rodríguez-Morán et al who undertook a community-based cross-sectional study of 488 apparently healthy children aged 10–13 years to assess the hypothesis that magnesium deficiency is associated with elevated high-sensitivity C reactive protein (hsCRP) levels (1). The headline of the article is ‘’Serum magnesium and C-reactive protein levels’’ whereas in their study the authors wrote th...

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  • Giant cell astrocytomas in Tuberous Sclerosis Complex
    David Neal Franz, MD

    June 30, 2008

    To the Editor: We read with interest the study by O’Callaghan et al.1 The authors’ observations largely confirmed what was already known about giant cell astrocytomas (GCA) in tuberous sclerosis (TSC). However, we have serious concerns about the methodology and several of the conclusions drawn. Most importantly, they do not provide plausible evidence for their main clinical conclusion that screeni...

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  • Making targeted Hepatitis B vaccination work
    Cliona M Ni Bhrolchain

    I would support Kamal-Uddin and D’Costa’s call to the Department of Health to reconsider universal Hepatitis B immunisation, to bring the UK into line with WHO policy (1). However, a previous study challenges their conclusion that targeted immunisation is ineffective. We studied 61 women booked for antenatal care at Northampton General Hospital from 1981 to 1997 (2). We were able to show increasing success in completing...

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  • torasemide might be the diuretic of choice even in hypertension
    oscar,m jolobe

    The use of torasemide in paediatric patients with heart failure(1) is part of an increasing recognition that diuretics which activate the renin- angiotensin-aldosterone system(RAAS)might be detrimental in the long term,given the findings of an observational study using propensity score methods which documented an increased mortality risk(Hazard Ratio 1.31; 95% confidence interval 1.11-1.55; p=0.002)associated with chronic...

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  • Re: Use of appropriate inhaler devices for optimal delivery of inhaled corticosteroids
    Steve Turner


    Like Dr Sonnappa in London, I was very disappointed to see a picture on the front of this month’s Archives of a child using a pressurised metered dose inhaler (pMDI) without a spacer. This is the second such picture to appear on the front of Archives within the last 12 months and gives the wrong message to readers. The correct message is that pMDIs should not be used without a spacer device in children....

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  • Alcohol intake and pregnancy in Spain: A silent crisis
    Juan A Ortega-Garcia

    We would like to comment on aspects related to Elliott et al's report (1). Fetal Alcohol Syndrome (FAS) constitutes just the tip of the iceberg in the effects observable due to alcohol intake during pregnancy. The few abilities to detect and quantify alcohol intake, the culture of drinking in Mediterranean regions, and the low perception of risk in society makes it so that children are not diagnosed with FAS. However, man...

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  • Infant weighing, feeding and the obesity epidemic
    Ruth V Reed

    From my recent journey into parenthood, I have gained some worrying insights into the roots of obesity in infancy. Ideally, the nation’s breastfeeding rates would be far higher, but we must address the current reality that the majority of babies are primarily formula-fed for most of their first year. Numerous inappropriate bottle-feeding practices leading to excessive calorie intake are widespread, and health professio...

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  • physical activity and obesity-related outcomes
    Jurgen Damen

    We read with interest the article of Metcalf et al. on physical activity and obesity-related outcomes.1 The authors conclude a minimal physical activity of ¡Ý3 MET, the Government-recommended intensity, is associated with an improvement in metabolic health but not with a change in BMI.

    However, we have some concerns regarding this conclusion. First of all, the authors distinguished between boys and girls and su...

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  • Hyponatraemia and hypokalaemia due to intravenous hypotonic solutions in the children
    Ahmet Sert

    We read with interest the article by Armon et al who undertook a cross-sectional study of 99 children to determine the types and volumes of intravenous fluids given to children in hospital in the UK, estimate the prevalence of abnormal serum sodium and potassium levels, and evaluate the use of local clinical guidelines (1). In the methods of the article authors wrote that ‘’Patients on neonatal intensive care units were e...

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  • Benzathine penicillin is a cheap therapy for primary prevention of rheumatic fever
    Ahmet Sert

    Dear Editor,

    We read with interest the once-daily amoxicillin versus twice-daily penicillin V in group A b-haemolytic streptococcal pharyngitis recently issued by the Archives of Disease in Childhood (1).

    The universal sensitivity of GABHS isolates to penicillin makes this an effective therapeutic option when the entire 10-day course of treatment is given; however, the arduous dosing regimen is often a...

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