eLetters

1531 e-Letters

  • Should use of home-made spacers be incorporated into guidelines for asthma management?
    SK Agarwal

    Dear Editor

    Zar et al[1] found that lung deposition of aerolised technetium-99DTPA inhaled via modified 500 ml plastic bottle was higher compared to a Babyhaler in both young and other children. There was no difference in lung deposition when a mask was used. Though other workers[2] have recommended the attachment of facemasks to treat patients of all ages.

    In another study[3] children aged 5 to 13 years...

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  • Intestinal inflammation in cystic fibrosis
    G L Briars

    Dear Editor

    Following their studies of whole gut lavage fluid Smyth et al have suggested that a non-idiopathic intestinal inflammation occurs constituitively in CF patients, as a consequence of a proinflammatory effect of the patient's CFTR mutations.[1] They reported marginally elevated excretion of IgG, IgM, IL-1 , neutrophil elastase and eosinophil cationic protein, and much more significant increase in excreti...

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  • Controversy about MMR vaccinations in children with or without egg allergy
    Arnaldo Cantani

    Dear Editor,

    According to our studies 1803 children allergic to egg have been safely received the MMR vaccine. Systemic reactions were present only in 0.1% of cases and untoward reactions only in 1.7% cases (p = 0.0001).[1] No child vaccinated by us has manifested immediate reactions.[1] According to Sampson et al[2] the MMR vaccine is safe in such children, evaluating on the basis of confidence intervals (95%) t...

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  • Consider absolute risks in SIDS prevention
    Stuart Logan

    Sir

    The demonstration by Blair et al[1] of an association between poor postnatal growth and an increased risk of SIDS, is a useful addition to our understanding of the aetiology of this condition. It is unfortunate that the conclusion in the abstract that "Poor postnatal weight gain was independently associated with an increased risk of SIDS and could be identified at the routine six week assessment" (italics added...

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  • Re: Dietary products used in infants for treatment and prevention of food allergy
    Arnaldo Cantani
    Dear Editor

    We agree with the letter from Professor Koletzko suggesting that more studies in this field are necessary (Arch Dis Child Rapid Response 6 June 2000). However, Table 4 of my study detailed all the data of the "other authors" and tried to make a mean among all such data. Since Sampson et al documented a 0% prevelence of sensitisation to soy, we concluded that about "80-100%" of children.

    Professor...

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  • Re: Prone sleeping and circulatory control in infants
    Michael Healy

    I believe that Dr Narchi's worries about Chong et al's paper are unjustified.

    The t test is known to be in the technical sense robust to non- Normality, meaning that unless the departure from Normality is severe the t table p values are very close to the correct ones. From general experience the variables studied in the paper are likely to have distributions that are close to Normality.

    Choing et al st...

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  • Re: Sputum induction not more sensitive than gastric lavage
    Heather J Zar

    Reply to Dr Wiersma and colleagues:

    Dr Wiersma and colleagues suggest that the yield from a single sputum induction should be compared only with the results of those children who had 3 consecutive gastric lavages (Arch Dis Child Rapid Response 2 June 2000). Only 26 of our patients had 3 gastric lavages; amongst this subset however, 4 children were culture positive on sputum while only 3 were positive on gastric...

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  • Re: MMR vaccine in children allergic to egg
    Harvey Marcovitch

    Dr Riordan ask which expert opinion to follow. The answer surely lies in reading the papers carefully, seeking out any key references quoted and deciding for oneself who has provided the best evidence. This should be the case for all guidelines, but we know that they are often absorbed undigested, which is one reason why ADC erects fairly firm barriers to their publication. Lakshman and Finn's paper was commissioned b...

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  • Re: MMR vaccine in children allergic to egg
    Adam Finn

    Dear Editor:

    We note Riordan's response to our editorial on the issue of MMR vaccine and allergy[1] and the recommendations put forward by Khakoo and Lack[2] on this topic. While we agree that conflicting advice creates confusion, we cannot agree with his proposed "pragmatic approach". This amounts to a pointless waste of time and resources - greater than that proposed by anyone else to date - which will simply...

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  • MMR vaccine in children allergic to egg
    Andrew Riordan

    Dear Editor

    Two reviews of MMR vaccine and egg allergy have recently been published. [1, 2] One appears in the Royal College of Paediatrics and Child Health's own journal (Archives of Diseases in Childhood),[1] the other has been endorsed by the Committee on Infection and Immunisation of the Royal College of Paediatrics and Child Health.[2] The two articles differ in their recommendations of which children should be g...

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