153 e-Letters

published between 2012 and 2015

  • Faecal calprotectin as an effective diagnostic aid for necrotising enterocolitis
    Cathy Hammerman

    We read with great interest the recent Archimedes discussion entitled "Can faecal calprotectin be used as an effective diagnostic aid for necrotizing enterocolitis in neonates" by Houston and Morgan. In their commentary the authors correctly state that most of the studies used an ELISA method and that many local laboratories currently only run fecal calprotectin testing in once or twice weekly, which would not support it...

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  • Pickled Red Herrings
    Michael A. Colvin

    Wolfe et al heighten my anxiety about solution- focussed epidemiological research with their recommendations for improving child survival in the UK (1). The correlation of lower socio- economic inequality with better child health outcomes in Sweden is clear enough but correlation does not equal causation, as we never tire of hearing. The assertion that "child survival in Britain would be improved through macroeconomic po...

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  • Where do the differences in childhood mortality rates between England & Wales and Sweden originate?
    Anna M. Zylbersztejn

    We support the call for action by Wolfe et al. to address UK's high child mortality rates relative to some other European countries (e.g. Sweden) and we agree that preventive public health strategies are crucial for reducing child mortality in the UK. To put these aspirations into practice policy makers need to know which populations to target. In particular, whether the priority should be to focus on the health of women...

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  • Cross-sectional presentation of longitudinal data
    Rollo D Clifford
    The authors of this study are to be congratulated on a unique and useful collection of data which, in the present climate, is increasingly difficult to achieve. Unfortunately the title is somewhat misleading and the abstract potentially open to mis-interpretation. Although parents collected diary data on their children during concurrent weeks, this is presented by the authors in a cross sectional, not longitudinal manner. Thus, wh...
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  • A useful tool for parents
    Ilana R Levene

    I agree with the editorialists that bed sharing is a decision that each parent must make based on their own risk profile and the benefits that they receive. A dogmatic single message approach is not appropriate for this widespread practice when it has such a small affect on absolute risk of SIDS in many families. I would like to bring to their attention a very useful app (available for android and apple devices) from the...

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    Davendralingam Sinniah

    I read with great interest the arguments whether 0.9% saline with 5% dextrose would be a more appropriate choice than 0.45% saline with 5% dextrose for maintenance fluids in hospitalized children. In 1975, WHO and the United Nations Children's Fund (UNICEF) decided to promote a single ORS (WHO-ORS) containing (in mmol/L) sodium 90, potassium 20, chloride 80, base 30, and glucose 111 (2%) for use among diverse populations....

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  • Should 0.9% saline be used for maintenance fluids in hospitalised children?
    Graham C. Smith

    I just have a simple question for Dr Morgan in relation to her Archimedes article entitled "Should 0.9% saline be used for maintenance fluids in hospitalised children?"[1]. Is she telling me that the recommended maintenance sodium intake for a 10kg child who would normally be prescribed 1000 mls/day of fluid based on 100 mls/kg/day, is 150 mmol or 15 mmol/kg/day. This is far in excess of the recommended NaCl intake of 2g...

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  • Oral salbutamol is of use in other settings too
    Anthony Cohn

    I have always been confused at the bad reputation acquired by oral salbutamol which, in the UK, has been confined to pharmacological oblivion on the contradictory premises that it is both ineffective and responsible for unacceptable side effects. Paradoxically, intravenous salbutamol is becoming evermore popular in the treatment of severe asthma. Given the acceptance that intravenous salbutamol is effective, oral salbutam...

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  • Invertase is an alternative to Sucraid in the treatment of CSID
    Iain S. Chalmers

    We read with interest the article by Puntis and Zamvar(1), reporting their experience of children with congenital sucrase-isomaltase deficiency (CSID) including response to enzyme replacement therapy with Sucraid (sucrasidase). We report our own experience of a child with CSID which offers an additional perspective and therapeutic option. Our patient is a girl who was diagnosed with CSID at 8 months of age. She was refer...

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  • Patient with Non Ketotic Hyperglycinemia
    Rachael Fawcett

    I came upon this article by chance and realised it is infact my daughter Emilys case.She was born on 10/11/11 and passed away from nkh on 16/11/11.Knowing her case has been used to highlight non ketotic hyperglycinemia is very heartwarming.I am in daily contact with families with children living with this terrible condition and they all remain positive a cure will eventually be found,i am aware researchers in the uk hav...

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