197 e-Letters

published between 2009 and 2012

  • The link between increased lactate production and mortality in pneumonia
    Michael Eisenhut

    A recent study established increased lactate levels as a predictor for mortality from pneumonia. X-ray abnormalities were increased in patients with elevated lactate levels (1). Recent work established that prophylactic specific inhibition of nitric oxide production by N- acetylcysteine leads to a reduced lactate production as well as a reduced severity of lung injury in an animal model of sepsis induced lung injury (2)....

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  • Vaccines and disparities in male and female infant mortality in Guinea-Bissau: the problem of small numbers, high attrition rates and incomplete reporting
    Carsten Kruger

    Peter Aaby and colleagues present again highly controversial data in the Archives, namely that vaccines have non-specific effects on infant survival depending on the timing and sequence of vaccines and on sex.[1] The same research group has already published many articles on this topic which have generated much debate [2-4] without reaching a final conclusion whether their claims are correct or not (for a full publication...

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  • The possible cause for the rapid rise in incidence of Irish paediatric inflammatory bowel disease
    Xiaofa Qin

    I read with interest the article by Hope B et al recently published online in Arch Dis Child regarding the rapid rise in incidence of Irish paediatric inflammatory bowel disease (IBD)[1]. I just published a paper on World Journal of Gastroenterology with a unified hypothesis regarding the etiology of IBD, including the possible cause and mechanism of IBD as well as the relationship between ulcerative colitis and Crohn's...

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  • Chickenpox in the immunocompromised child
    Ajmal Kader

    I read with interest the article by Roderick et al. Authors seem to recommend post exposure prophylaxis with aciclovir from day 7 onwards for 7 days for immunocompromised patients. Whilst there is good evidence for such use in immunocompetent subjects to enable development of effective immunity and suppress the clinical disease, there is no good evidence for its use in immunocompromised patients. In fact your references...

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  • An 18th century opinion on electrical stimulation on a child with cerebral palsy
    Andrew N Williams

    It was good to read Wright et al's paper about an evolving understanding of a role for electrical stimulation for children with cerebral palsy [1]. However the search strategy missed a relevant and enlightening history. The English Physician Erasmus Darwin (1731-1802) used electricity to treat childhood cerebral palsy more than a decade before Luigi Galvani (1737-1798) made electricity popular.

    Mary Ann Wedgwo...

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  • Re:Don't Excise -- Exorcise
    Alison H Stubbings

    We'd like to thank Dr Litt for informing us that he was the first to comment on this treatment method (1) and apologise for having missed this in our review (2). We would, however, add that the function of a short evidence-based review like Archimedes is to weigh the evidence for the treatment, and in particular look at when it has been subjected to trials. Harsh as it might seem, this sadly rarely includes the initial di...

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  • Re:Clear duct tape based wart studies are flawed
    Alison H Stubbings

    Thank you, Prof Samlaska, for your response to our article (1). It is indeed interesting the difference between traditional and clear duct tape, and this is something that we did not consider in our review. It would be worth noting however, that I think it is unlikely that the families to whom this treatment is suggested would consider this difference either.

    I agree more work should be done looking at this thera...

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  • The importance of thorough investigation of children with chronic wet cough
    Malcolm Brodlie

    Dear Editor,

    We read with interest the recent paper by Lim et al. reporting the prevalence of specific polysaccharide antibody deficiency in a cohort of 96 children with chronic wet cough.[1] Specific polysaccharide antibody deficiency was defined in terms of inadequate pneumococcal serotype- specific antibody levels following immunisation with Prevenar and/or Pneumovax II. Results of other immunological investi...

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  • accent might be a confoundind factor
    oscar,m jolobe

    The fact that non white patients gave higher scores to white doctors than to non-white doctors(1) might be attributable to a greater extent to diction than to ethnicity. In all sections of society and, in my own experience, especially among some ethnic minorities, an authoritative delivery which is characterised by "polished" vowels and "clipped" consonants inspires greater trust and confidence than a comparable deliver...

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  • Longitudinal CSII studies warrant a more refined statistical approach than simple t-tests
    Akash Sinha

    Dear Sir,

    We read with interest the observations made by Hughes et al but it is important for readers to be aware of the limitations of their means of data analysis.

    Hughes et al have combined all the pre-CSII HbA1c values and calculated a mean HBA1c (Referred to as Pre-CSII HbA1c) and then compared this with subsequent post CSII HBA1c measurements at different time points. The problem with this method...

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