Do antipyretics prevent febrile seizures?

Schnaiderman D, et al. Eur J Pediatr 1993; 152: 747-749


3 part question: �In children who have experienced a febrile seizure (patient): does prescribing antipyretics (intervention) reduce recurrence of febrile seizures (outcome)?�


Search terms:All EBM reviews � Cochrane Library and DARE �, Prodigy, Evidence Based Clinical guidance, and Pubmed and Medline (Ovid): Febrile convulsions/ seizures (FS) and antipyretics, paracetamol, and ibuprofen


Patients key clinical characteristics: Children (aged 6 months to 5 years) who presented with an episode of simple febrile seizures.


Control regimens: After their febrile seizures, children were randomly allocated to receive paracetamol at regular intervals (n=53) versus sporadic use of paracetamol contingent upon a presence of fever (n=51).


Study features: RCT, not placebo-controlled, not blinded


Evidence summary: While in-patient rectal temperature was monitored routinely at 4 h intervals, or every 30 min whenever there is fever


Clinical bottom line: Prophylactic administration of paracetamol is not effective in the prevention of fever, the reduction of its degree, or in preventing the early recurrence of FS


Citation: Schnaiderman D, Lahat E, Sheefer T, Aladjem M. Antipyretic effectiveness of acetaminophen in febrile seizures: ongoing prophylaxis versus sporadic usage. Europ J Pediatr 1993; 152:747-749


Contact Details: A. Sahib El-Radhi, Consultant Paediatrician, Queen Mary�s Hospital, Sidcup.