Do antipyretics prevent febrile seizures?
Cochrane
Database of systemic review
Meremikwa
M et al 2002
The Cochrane Database of Systemic Reviews
2002; 4
3
part question
�In children who have experienced a febrile seizure (patient): does
prescribing antipyretics (intervention) reduce recurrence of febrile seizures
(outcome)?�
Search terms
the Cochrane infectious Diseases Group specialised trials register, the Cochrane
Controlled Trials Register, Medline (1966-2001), EMBASE (1988-2001), LILACS,
Science Citation Index, reference lists of articles
Patients
key clinical characteristics
12
trials, number of children=1509 (compared paracetamol to placebo and trials
compared paracetamol to physical methods) of children with fever. The primary
outcomes were fever clearance time and febrile convulsion.
Study features
All
randomised and quasi-randomised trials
Evidence summary
systematic
review looking for the number of recurrence of FS
Clinical
bottom line
The
trails failed to demonstrate any convincing evidence that paracetamol is
effective in reducing fever or preventing FS
Citation
Meremikwu M, Oyo-Ita A.
Paracetamol for treating fever in children
The Cochrane
Database of Systemic Reviews 2002; 4
Contact Details
Sahib El-Radhi, Consultant Paediatrician, Queen Mary�s Hospital, Sidcup
Email: sahib.el-radhi@qms.nhs.uk