Article Text

Download PDFPDF
Multifocal tuberculosis: a phenotype of Mendelian susceptibility to mycobacterial disease
  1. Pierre Gourdan1,
  2. Ivana Colanic2,
  3. Sibylle Blanc1,
  4. Agnès Fina1,
  5. Marie Baque-Juston3,
  6. Federico Solla4,
  7. Ana Giordano4,
  8. Thomas Hubiche5,
  9. Pierre Rohrlich6,
  10. Vincent Barlogis7,
  11. Jacinta Bustamante8,
  12. Stéphanie Boisson-Dupuis8,
  13. Lisa Giovannini-Chami1
  1. 1Pediatric Pulmonology and Allergology Department, Hôpitaux Pédiatriques de Nice CHU-LENVAL, Nice, France
  2. 2Pediatric Emergency Department, Hôpitaux Pédiatriques de Nice CHU-LENVAL, Nice, France
  3. 3Pediatric Radiology Department, Hôpitaux Pédiatriques de Nice CHU-LENVAL, Nice, France
  4. 4Pediatric Surgery Department, Hôpitaux Pédiatriques de Nice CHU-LENVAL, Nice, France
  5. 5Pediatric Dermatology Department, CHU Nice, Nice, France
  6. 6Pediatric Hematology Department, CHU Nice, Nice, France
  7. 7Pediatric Hematology Department, APHM, Timone Enfant, Marseille, France
  8. 8Imagine Institute, Paris, France
  1. Correspondence to Dr Pierre Gourdan, Pediatric Pulmonology and Allergology Department, Hôpitaux Pédiatriques de Nice CHU-LENVAL, 57 Av. de la Californie, 06200 Nice, France; pierre.gourdan{at}hpu.lenval.com

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

A just over 1-year-old girl presented with a history of multifocal tuberculosis. The patient was born at full-term in Madagascar. She was not BCG vaccinated. At 8 months old, she had measles complicated by pneumonia, with a persistent cough treated with prolonged high-dose oral corticosteroids. At 12 months old, pulmonary, cutaneous and otitic tuberculosis was diagnosed in Madagascar. Testing was positive for non-drug-resistant Mycobacterium tuberculosis in sputum (PCR) and otorrhoea (PCR, culture). Quadruple anti-tuberculosis antibiotherapy was initiated, but adherence to treatment was poor.

On evaluation at our centre 2 months after initiation of treatment, we noted progression of the multifocal tuberculosis …

View Full Text

Footnotes

  • PG and IC contributed equally.

  • JB and SB-D contributed equally.

  • Contributors PG, IC and LG-C drafted the initial manuscript, participated in the conceptualisation of the case report, performed a complete review of the current literature, critically revised the manuscript and approved the final manuscript as submitted. SB, AF, MB-J, FS, AG and TH are involved in follow-up of the patients, critically revised the manuscript and approved the final manuscript as submitted. PR, VB, JB and SB-D contributed to the genetic part of diagnosis, critically revised the manuscript and approved the final manuscript as submitted.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.