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Early detection of gastrointestinal polyps and neoplasia following radiation for childhood-onset cancer
  1. Gabby Atlas1,2,3,
  2. Margaret Rosemary Zacharin1,2,3
  1. 1Department of Endocrinology, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
  2. 2Murdoch Children's Research Institute, Melbourne, Victoria, Australia
  3. 3Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
  1. Correspondence to Dr Gabby Atlas, Endocrinology, The Royal Children's Hospital Melbourne, Parkville, VIC 3052, Australia; gabby.atlas{at}

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A massive and rapidly increasing burden of care exists for all physicians caring for the 80–90% of childhood cancer survivors. All paediatricians and general practitioners (GPs) seeing these adolescents must attain a sound knowledge of the risks, current and future, faced by these young people. Provision of improved care and appropriate surveillance during adolescence, with information for adult services at time of transition, will also empower patients and their families to advocate for and act upon the essential requirements for long-term surveillance. Not all these risks are yet commonly recognised.

Exposure to abdominal radiation for childhood cancer increases risks of gastrointestinal polyps and colorectal cancer (CRC), level comparable with two or more first-degree relatives with CRC.1 Radiation-associated CRC is defined by malignancy arising within the field of prior abdominal radiation, usually ≥10 years after irradiation.

Consensus recommendation and firm clinical guidelines from both the Children’s …

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  • Contributors All authors contributed to the study conception and design. Data collection was performed by both GA and MRZ. The first draft of the manuscript was written by GA and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.