You are here

Article Text

Article menu
Download PDFPDF
Original research
Advanced chronic kidney disease among UK children
  1. Lucy Plumb1,2,
  2. Winnie Magadi1,
  3. Anna Casula1,
  4. Ben C Reynolds3,
  5. Mairead Convery4,
  6. Shuman Haq5,
  7. Shivaram Hegde6,
  8. Andrew Lunn7,
  9. Michal Malina8,9,
  10. Henry Morgan10,
  11. Mordi Muorah11,
  12. Kay Tyerman12,
  13. Manish D Sinha13,
  14. Dean Wallace14,
  15. Carol Inward15,
  16. Stephen Marks16,17,
  17. Dorothea Nitsch1,18,
  18. James Medcalf1,19
  1. 1 UK Renal Registry, UK Kidney Association, Bristol, UK
  2. 2 Population Health Sciences, University of Bristol Medical School, Bristol, UK
  3. 3 Department of Paediatric Nephrology, Royal Hospital for Children Glasgow, Glasgow, UK
  4. 4 Department of Paediatric Nephrology, Royal Belfast Hospital for Sick Children, Belfast, UK
  5. 5 Department of Paediatric Nephrology, Southampton Children's Hospital, Southampton, UK
  6. 6 Department of Paediatric Nephrology, University Hospital of Wales, Cardiff, UK
  7. 7 Department of Paediatric Nephrology, Nottingham University Hospitals NHS Trust, Nottingham, UK
  8. 8 National Renal Complement Therapeutics Centre, Great North Children's Hospital, Newcastle Upon Tyne, UK
  9. 9 Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
  10. 10 Department of Paediatric Nephrology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK
  11. 11 Department of Paediatric Nephrology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK
  12. 12 Department of Paediatric Nephrology, Leeds Children's Hospital, Leeds, UK
  13. 13 Department of Paediatric Nephrology, Evelina London Children's Hospital, London, UK
  14. 14 Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Manchester, UK
  15. 15 Department of Paediatric Nephrology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK
  16. 16 Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
  17. 17 NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health, London, UK
  18. 18 Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
  19. 19 Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
  1. Correspondence to Dr Lucy Plumb, UK Renal Registry, Bristol, Bristol, UK; lucy.plumb{at}bristol.ac.uk

Abstract

The UK Renal Registry currently collects information on UK children with kidney failure requiring long-term kidney replacement therapy (KRT), which supports disease surveillance and auditing of care and outcomes; however, data are limited on children with chronic kidney disease (CKD) not on KRT.

Methods In March 2020, all UK Paediatric Nephrology centres submitted data on children aged <16 years with severely reduced kidney function as of December 2019, defined as an estimated glomerular filtration rate <30 mL/min/1.73 m2.

Results In total, 1031 children had severe CKD, the majority of whom (80.7%) were on KRT. The overall prevalence was 81.2 (95% CI 76.3 to 86.3) per million of the age-related population.

Conclusions The prevalence of severe CKD among UK children is largely due to a high proportion of children on long-term KRT. Expanding data capture to include children with CKD before reaching failure will provide greater understanding of the CKD burden in childhood.

  • Paediatrics
  • Nephrology
  • Epidemiology

This article is made freely available for personal use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.

https://bmj.com/coronavirus/usage

https://doi.org/10.1136/archdischild-2021-323686

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Twitter @ledicmucy

    • Contributors LP, SM, CI, DN and JM designed and coordinated the data collection process in response to COVID-19 infection concerns for children with kidney disease; CI, MC, S Haq, S Hegde, AL, MM, HM, MM, SM, BR, MDS, KT and DW collated centre data; WM and AC analysed data; LP drafted and revised the manuscript with intellectual input from the authors.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests LP declares funding from the National Institute for Health Research (NIHR) and Kidney Research UK (KRUK). BCR declares funding from KRUK, honoraria from Alexion Pharmaceuticals and Magnolia Innovation, and consultancy payment from Chiesi. MM reports previous honoraria and travel expenses from Alexion. SM declares a role as head of the UK Renal Registry Audit and Informatics group. KT declares a role as clinical lead of the National Institute for Health and Care Excellence Medical Technologies Advisory Committee during the study period. DN declares funding/payment from the Health Foundation, UK Kidney Association, Chiang Mai University and GSK.

    • Provenance and peer review Not commissioned; externally peer reviewed.