Background The prevalence of and risk factors for neurological problems in childhood coeliac disease (CD) are unclear.
Methods We performed a cross-sectional, community-based audit of CD in children diagnosed from January 2010 to December 2016 in Lothian.
Results 79 (28%) of 284 children with CD (201, 70.8% female) (mean age 8.3 years, range of 1–16) had neurological problems. Fifteen (5.3%) had headaches/migraine, 10 (3.5%) anxiety, 8 (2.8%) motor/co-ordination problems / ataxia (there were no patients with ataxia), 7 (2.5%) had behavioural issues, 5 (1.8 %) with ASD, 5 (1.8%) low mood, 4 (1.4%) ADD/ ADHD, 3 (1.1%) seizures and 2 (0.7%) had neuropathy. Neurological problems were more common with later age at CD diagnosis (OR 1.07, 95% CI 1.01 to 1.14) and male gender (OR 1.69, 95% CI 0.96 to 2.95).
Conclusion Prevalence of neurological problems in children with CD in Lothian is lower than published adult CD studies and similar or lower to the reported prevalence in the general childhood population.
Data availability statement
Data are available upon reasonable request.
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Correction notice This paper has been corrected since it was first published. The wording and some numbers and percentages in the abstract do not match the supplementary table data. In the abstract, the results section has been changed to the following: Fifteen (5.3%) had headaches/migraines, 10 (3.5%) anxiety, 8 (2.8%) motor/co-ordination problems/ataxia (there were no patients with ataxia), 7 (2.5%) had behavioural issues, 5 (1.8 %) with ASD, 5 (1.8%) low mood, 4 (1.4%) ADD/ ADHD, 3 (1.1%) seizures and 2 (0.7%) had neuropathy. In Table 1, in the heading Neurological problems, No, N=145 stated, this is incorrect and has been corrected to No (N=205). In the supplementary table, the Autism/ASD percentage in the study cohort column should read 1.8% and this has also been updated.
Contributors Original database work conducted by PW, DB and DP. Data analyses and prinicipal drafting of manuscript by TO'N, PG and RC. Study conceptualisation and design by PG and RFC.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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