There are several important relapsing demyelinating syndromes (RDS) that may present in childhood, of which paediatric-onset multiple sclerosis is the most common. These are rare conditions, so recognising presentations and referring early to specialist services is important to enable prompt diagnosis and effective treatment. Understanding of RDS is rapidly evolving, with many new and effective treatments that aim to reduce relapses and disability accumulation. A holistic and child-focused approach to management is key to supporting patients and families, with thought given to early detection of cognitive and psychological issues to provide appropriate support.
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Contributors ALS, CH and ML constructed main components of the review. ALS drafted the initial manuscript, designed the figures and tables. CH, ML and NS reviewed, revised and refined all versions of the manuscripts.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests CH has received educational grants from Biogen and provided consultant advice for Novartis, VielaBio and Biogen. Dr Ming Lim receives research grants from Action Medical Research, the DES Society, GOSH Charity, National Institute for Health Research, MS Society and SPARKS Charity; receives research support grants from the London Clinical Research Network and Evelina Appeal; has received consultation fees from CSL Behring, Novartis and Octapharma; received travel grants from Merck Serono; and was awarded educational grants to organise meetings by Novartis, Biogen Idec, Merck Serono and Bayer.
Provenance and peer review Not commissioned; externally peer reviewed.
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