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Shiga toxin-producing Escherichia coli carriage in 959 healthy French infants
  1. Etienne Bizot1,
  2. Aurelie Cointe1,2,
  3. Stéphane Béchet3,
  4. Elsa Sobral3,
  5. Robert Cohen3,4,
  6. Patricia Mariani-Kurkdjian1,2,
  7. Corinne Levy3,4,
  8. Stephane Bonacorsi1,2
  1. 1Service de microbiologie, Centre National de Référence associé Escherichia coli, Hopital Universitaire Robert Debre, Paris, Île-de-France, France
  2. 2Université de Paris, IAME UMR1137, INSERM, F-75018 Paris, Île-de-France, France
  3. 3Association Clinique Therapeutique Infantile du Val de Marne, ACTIV, Saint-Maur-des-Fossés, France
  4. 4Université Paris Est, IMRB-GRC GEMINI, ACTIV, Créteil, France
  1. Correspondence to Professor Stephane Bonacorsi, Microbiology Laboratory, Hopital Universitaire Robert Debre, Paris 75019, France; stephane.bonacorsi{at}aphp.fr

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Shiga toxin-producing Escherichia coli (STEC) infection can cause simple diarrhoea but also life-threatening haemolytic and uraemic syndrome (HUS) in infants. Diagnosis is based on amplification of genes encoding the Shiga toxin (stx) on stools.1 The increasing ability to detect STEC due to the availability of multiplex PCR raises questions concerning the interpretation by clinicians of a positive PCR for patients with acute diarrhoea. Therefore, knowledge of the rate of asymptomatic carriage among young infants is needed. We assessed the rate of STEC carriage in a large cohort of children less than 2 years old, at risk of HUS in France, irrespective of their modality of care.

This work is an ancillary study of a longitudinal survey of faecal Enterobacterales antimicrobial resistance performed in children aged 6–24 …

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Footnotes

  • Contributors EB performed experiments, collected data, drafted the initial manuscript, and reviewed and revised the manuscript. AC and SBo conceptualised and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. SBé and CL performed statistical analysis and reviewed and revised the manuscript. ES collected data. RC and PM-K critically reviewed the manuscript for important intellectual content.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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