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Paediatric critical care referrals of children with diabetic ketoacidosis during the COVID-19 pandemic
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  1. Emre Basatemur1,
  2. Andrew Jones1,
  3. Mark Peters2,
  4. Padmanabhan Ramnarayan1
  1. 1Children's Acute Transport Service, Great Ormond Street Hospital for Children, London, UK
  2. 2Department of Paediatric Intensive Care, Great Ormond Street Hospital for Children, London, UK
  1. Correspondence to Dr Emre Basatemur, Children's Acute Transport Service, Great Ormond Street Hospital for Children, London WC1N 3JZ, UK; emre.basatemur{at}ucl.ac.uk

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Child health practitioners in the UK and internationally have voiced concerns that restrictions and measures introduced to combat the COVID-19 pandemic may be causing unintended adverse consequences for the health and social well-being of children. Initial reports suggested a significant reduction in the utilisation of healthcare services by children during the pandemic, raising concerns about late presentation of children with serious illness.1 In a national survey of UK paediatricians, 32% of clinicians reported having witnessed delayed presentations to emergency care over a 2-week period in April 2020.2 The most frequently reported delayed presentation was new diagnosis of diabetes mellitus. Analysis of children newly diagnosed with type 1 diabetes in Germany identified that between March and April 2020, a significantly greater proportion of cases presented with diabetic ketoacidosis (DKA) (45%) when compared with corresponding periods over the previous 2 years (24%).3

Here, we report the frequency of referral of children with DKA to a regional paediatric critical care advice and transport service in the UK, before and during the COVID-19 pandemic. We also report overall referral activity to the service during these periods for comparison. We included all children up to 15 years of age with a confirmed diagnosis of DKA (based on national criteria).4 Two children referred from overseas for repatriation to the UK were excluded.

Thirty-one children were referred with DKA between March and July 2020, compared with a median of 12 (range 11–20) over corresponding months in the preceding 5 years (figure 1). In comparison, overall referrals to the service were lower during the pandemic period compared with previous years (figure 1).

Figure 1

DKA referrals and overall referrals by month, comparing 2020 with the preceding 5 years.

We explored whether there was any difference in the severity of DKA cases referred before and during the pandemic by comparing the clinical characteristics of 105 children referred between January 2018 and February 2020 with those of 31 children referred between March and July 2020. There were no significant differences between the groups in reported duration of symptoms prior to hospital attendance, blood gas analysis parameters at presentation, intensive care unit admission rates or intubation rates (table 1). Findings were similar when the prepandemic comparison group was limited to the months of March–July (to exclude seasonal variation).

Table 1

Comparison of demographic and clinical characteristics of children referred with DKA during, and prior to, the COVID-19 pandemic

In summary, we observed an increase in referral of children with DKA during the COVID-19 pandemic compared with previous years, at a time when overall referral activity to the service was lower than usual. There are various possible explanations for this observation. Reduced access to primary care services and/or parental anxiety about presenting to healthcare providers during the pandemic period may have contributed to later diagnosis of new cases of type 1 diabetes (with a higher likelihood of DKA at the time of diagnosis). Changes in the organisation of regional paediatric services during the pandemic, with closure of children’s inpatient units at a number of district general hospitals to accommodate a predicted surge in acutely unwell adults, may have influenced the threshold for requests to our service for transport of cases (although clinical severity among referred cases was unchanged). There has also been speculation that COVID-19 infection may itself trigger the development of ketoacidosis via direct damage to pancreatic beta cells, based on observations that other coronaviruses bind to ACE2 receptors expressed by these cells.5

This study is limited by its small size, and the increase in cases observed during the pandemic period may have occurred by chance alone. Furthermore, the study cohort is limited to children referred for critical care advice. Interrogation of larger, nationally representative datasets that capture the overall occurrence of DKA in children would be beneficial to further investigate whether there has been a true increase in incidence during the pandemic period.

References

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Footnotes

  • Contributors AJJ, PR and MJP conceptualised and designed the study. EB and AJJ collected and analysed the data. EB drafted the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Disclaimer While this project received no specific funding, all research at Great Ormond Street Hospital NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health is made possible by the NIHR Great Ormond Street Hospital Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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