Article Text

Download PDFPDF
Impact of rituximab on anthropometric indices among childhood steroid-dependent nephrotic syndromes
  1. Rajiv Sinha1,
  2. Sushmita Banerjee2,
  3. Anwesha Mukherjee1,
  4. Shakil Akhtar3,
  5. Subal Pradhan4
  1. 1Division of Paediatric Nephrology, Institute of Child Health, Kolkata, West Bengal, India
  2. 2Department of Paediatric Medicine, Calcutta Medical Research Institute, Kolkata, West Bengal, India
  3. 3Division of Paedaitric Nephrology, Institute of Child Health, Kolkata, West Bengal, India
  4. 4Department of Paediatric Medicine, Sardar Vallabhbhai Patel Post Graduate Institute of Paediatrics, Cuttack, Orissa, India
  1. Correspondence to Dr Rajiv Sinha, Institute of Child Health, Kolkata, West Bengal 700019, India; rajivsinha_in{at}yahoo.com

Abstract

Background There is scarcity of data on impact of rituximab on anthropometrical parameters (weight, height and body mass index i.e. BMI SD score (SDS)) among children with steroid-dependent nephrotic syndromes (SDNS).

Methods Multicentre retrospective review.

Results 102 children with SDNS (male: 63%; n=64), median age 7 (IQR: 4.3–9.6) years, received a total of 217 rituximab infusions (total 110 cycles). At median follow-up of 2.1 (IQR: 1.3–2.8) years, 58 (57%) children were off steroids and a significant fall in steroid threshold for relapse was noted (median 0.6; IQR 0.4–0.9 to median 0.3; IQR 0.12 - 0.5 mg/kg/alternate day, p=0.005). Anthropometric parameters (BMI SDS: 0.92±1.8 to 0.25±1.47, p=0.003; weight SDS: 0.20±1.6 to −0.11±1.3, p=0.01; and height SDS: −0.93±1.88 to −0.45±1.54, p=0.04) as well as obesity (38% to 20%, p=0.003) and short stature (11% to 3%, p=0.02) improved. Results remained significant even when analysis was restricted to children ≤12 years (n=88), (BMI SDS: 0.97±1.98 to 0.25±1.5, p=0.001; weight SDS: 0.33±1.6 to 0.02±1.2, p=0.01; and height SDS: −0.67±1.84 to −0.186±1.42, p=0.001).

Conclusions Use of rituximab resulted in significant steroid sparing effect with an improvement in both growth and obesity parameters.

  • nephrology
  • therapeutics
View Full Text

Statistics from Altmetric.com

Footnotes

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Ethical approval was obtained (ICH/51/2017).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.