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Contributors BT: study concept and design, acquisition and analysis of data, preparation of manuscript including figures. KT-G: preparation and interpretation of the figures. FT: study concept and design, data acquisition and interpretation, critical revision.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Parental/guardian consent obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
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