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In November 2017’s issue of Archives there were a number of articles addressing the important area of the clinical approach to children with developmental delay. The investigations performed are very variable across the UK and this is a key area where the clinical and cost-effectiveness of every laboratory investigation needs to be further evaluated. Hart et al1 suggest a very limited metabolic screen for children with developmental delay without additional features, whereas Mithyantha et al2 suggest more extensive metabolic screening.
We cannot agree with the very limited metabolic screen proposed by Hart et al1 for children with developmental delay without additional features. We agree …
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