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Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study
  1. Yim-Yee Matthews1,
  2. Fiona Dean2,
  3. Ming J Lim3,
  4. Karen Mclachlan4,
  5. Alan S Rigby5,
  6. Guirish A Solanki6,
  7. Catharine P White7,
  8. William P Whitehouse8,
  9. Colin R Kennedy9
  1. 1Paediatric Department, Wrexham Maelor Hospital, Wrexham, UK
  2. 2Ophthalmology Department, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK
  3. 3Department of Children's Neurosciences, Evelina London Children's Hospital, Guy's and St Thomas’ NHS Foundation Trust, King's Health Partners Academic Health Science Centre, London, UK
  4. 4Paediatric Department, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK
  5. 5Division of Cardiovascular and Respiratory Medicine, University of Hull, Hull, UK
  6. 6Department of Paediatric Neurosurgery, Birmingham Children's Hospital, University of Birmingham, Birmingham, UK
  7. 7Department of Child Health, Morriston Hospital, Swansea, UK
  8. 8Department of Paediatric Neurology, School of Medicine, University of Nottingham, Nottingham University Hospitals NHS Trust, Nottingham, UK
  9. 9Clinical Neurosciences, Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, UK
  1. Correspondence to Dr Yim-Yee Matthews, Paediatric Department, Wrexham Maelor Hospital, Croesnewydd Road, Wrexham LL13 7TD, UK; yim-yee.matthews{at}wales.nhs.uk

Footnotes

  • Contributors The surveillance study was designed by Y-YM with key input from KMc and FD in the development of study protocol and survey questionnaires. WPW, CRK and CPW provided oversight of the surveillance study conducted by Y-YM. Y-YM, FD, KMc, CPW, WPW and CRK evaluated the eligibility of notifications. Y-YM analysed and interpreted the collected data. ASR advised and provided input in the statistical analysis. Y-YM did the literature reviews, drafted and revised all versions of the manuscript. CRK together with contributions from all others (WPW, MJL, CPW, FD, KMc, GAS and ASR) involved in the data interpretation, revised all versions and approved the final version of the manuscript.

  • Funding This national survey was supported by the BPSU/RCPCH Sir Peter Tizard Research Bursary.

  • Competing interests MJL receives research grants from Action Medical Research, DES society, GOSH charity, NIHR, MS Society, SPARKS charity; receives research support grants from the London Clinical Research Network and Evelina Appeal; has received consultation fees from CSL Behring; received travel grants from Merck Serono and awarded educational grants to organise meetings by Novartis, Biogen Idec, Merck Serono and Bayer. GAS has been an investigator in MPSII clinical trials with Shire, has received speaker's honorarium and travel support from BioMarin.

  • Ethics approval The East London & the City Research Ethics Committee (07/Q0603/47), the Patient Information Advisory Group (PIAG/BPSU1-05[FT3]/2007) and the North Wales NHS Research & Development (JJ/jh/RP07/02/02).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement All authors are willing to share all unpublished data from the study with bona fide researchers. The database can be made available to them through discussion with the corresponding author and the BPSU.

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Footnotes

  • Contributors The surveillance study was designed by Y-YM with key input from KMc and FD in the development of study protocol and survey questionnaires. WPW, CRK and CPW provided oversight of the surveillance study conducted by Y-YM. Y-YM, FD, KMc, CPW, WPW and CRK evaluated the eligibility of notifications. Y-YM analysed and interpreted the collected data. ASR advised and provided input in the statistical analysis. Y-YM did the literature reviews, drafted and revised all versions of the manuscript. CRK together with contributions from all others (WPW, MJL, CPW, FD, KMc, GAS and ASR) involved in the data interpretation, revised all versions and approved the final version of the manuscript.

  • Funding This national survey was supported by the BPSU/RCPCH Sir Peter Tizard Research Bursary.

  • Competing interests MJL receives research grants from Action Medical Research, DES society, GOSH charity, NIHR, MS Society, SPARKS charity; receives research support grants from the London Clinical Research Network and Evelina Appeal; has received consultation fees from CSL Behring; received travel grants from Merck Serono and awarded educational grants to organise meetings by Novartis, Biogen Idec, Merck Serono and Bayer. GAS has been an investigator in MPSII clinical trials with Shire, has received speaker's honorarium and travel support from BioMarin.

  • Ethics approval The East London & the City Research Ethics Committee (07/Q0603/47), the Patient Information Advisory Group (PIAG/BPSU1-05[FT3]/2007) and the North Wales NHS Research & Development (JJ/jh/RP07/02/02).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement All authors are willing to share all unpublished data from the study with bona fide researchers. The database can be made available to them through discussion with the corresponding author and the BPSU.

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