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Anthropometric measures and prevalence trends in adolescents with coeliac disease: a population based study
  1. Amit Assa1,2,
  2. Yael Frenkel-Nir3,
  3. Ya'ara Leibovici-Weissman4,
  4. Dorit Tzur3,
  5. Arnon Afek2,5,
  6. Lior H Katz2,3,
  7. Zohar Levi2,4,
  8. Raanan Shamir1,2
  1. 1Institute of Gastroenterology, Nutrition and Liver Disease, Schneider Children's Medical Center, Petach Tikva, Israel
  2. 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  3. 3Medical Corps, Israel Defense Forces, Ramat-Gan, Israel
  4. 4Institute of Gastroenterology, Rabin Medical Center-Beilinson Campus, Petach Tikva, Israel
  5. 5Ministry of Health, Jerusalem, Israel
  1. Correspondence to Dr Amit Assa, Institute of Gastroenterology, Nutrition and Liver Disease, Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel-Aviv University, 14 Kaplan St., Petach-Tikva 4920235, Israel; dr.amit.assa{at}


Objectives To investigate the impact of coeliac disease (CD) diagnosis on anthropometric measures at late adolescence and to assess trends in the prevalence of diagnosed CD over time.

Design A population based study.

Patients Prior to enlistment, at the age of 17 years, most of the Israeli Jewish population undergoes a general health examination. Subjects' medical diagnoses are entered into a structured database.

Interventions The enlistment database was thoroughly searched for CD cases between the years 1988 and 2015. Medical records of 2 001 353 subjects were reviewed.

Main outcome measures Anthropometric measures at the age of 17 years.

Results Overall, 10 566 CD cases (0.53%) were identified and analysed. Median age at data ascertainment was 17.1 years (IQR, 16.9–17.4). Multivariable analysis demonstrated that boys with CD were leaner (Body Mass Index 21.2±3.7 vs 21.7±3.8, p=0.02) while girls with CD were shorter (161.5±6 cm vs 162.1±6 cm, p=0.017) than the general population. The prevalence of diagnosed CD increased from 0.5% to 1.1% in the last 20 years with a female predominance (0.64% vs 0.46%). CD prevalence was significantly lower in subjects of lower socioeconomic status and those of African, Asian and former Soviet Union origin.

Conclusions Adolescent boys with CD were leaner and girls with CD were shorter compared with the general population. However, the clinical relevance of the small differences suggests that when CD is diagnosed during childhood, final weight and height are not severely impaired. Our cohort reinforces the observed increase in diagnosed CD.

  • Adolescent Health
  • Gastroenterology
  • Growth
  • Epidemiology
  • Outcomes research

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