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Disseminated intravascular coagulation in paediatrics
  1. Revathi Rajagopal1,
  2. Jecko Thachil2,
  3. Paul Monagle3,4,5
  1. 1Paediatric Haemato-Oncology, Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia
  2. 2Department of Haematology, Manchester Royal Infirmary, Manchester, UK
  3. 3Department of Clinical Haematology, Royal Children's Hospital Melbourne, Melbourne, Australia
  4. 4Department of Paediatrics, University of Melbourne, Melbourne, Australia
  5. 5Haematology Research, Murdoch Children Research Institute, Melbourne, Australia
  1. Correspondence to Professor Paul Monagle, Department of Paediatrics, University of Melbourne, 50 Flemington Road, Parkville, VIC 3052, Australia; Paul.Monagle{at}


Disseminated intravascular coagulation (DIC) in paediatrics is associated with significant morbidity and mortality. Although there have been several recent advances in the pathophysiology of DIC, most of these studies were done in adults. Since the haemostatic system is very different in early life and changes dramatically with age, creating a variety of challenges for the clinician, delay in the diagnosis of DIC can happen until overt DIC is evident. In this review article, we report the aetiology, pathophysiology, clinical manifestations, diagnostic tests and a management algorithm to guide paediatricians when treating patients with DIC.

  • Disseminated intravascular coagulation
  • Paediatrics
  • Diagnosis
  • Management

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