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Abstracts from the Neonatal and Paediatric Pharmacists Group (NPPG) 20th Annual Conference, 7–9 November 2014, Nottingham, UK

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Roshni Kankali1

Daniel Kirby1

Astrid Gerrard2

1School of Pharmacy, Aston University

2Birmingham Children's Hospital NHSFT

Administration of nifedipine, a short acting calcium channel blocker used to treat acute and chronic hypertension in paediatric patients, has been associated with large variations in treatment response to individual doses.1 Currently, there is no licensed paediatric nifedipine formulation available in the UK. The aim of this project was to determine the accuracy and precision of methods used in clinical practice to prepare paediatric doses of enteral nifedipine.

Method Initially, qualitative data collection and observational studies using questionnaires to identify common preparation techniques used by nursing staff were performed at one children's hospital.

Weight and content uniformity of split and crushed modified release nifedipine tablets (Nifedipressâ MR 10), and an imported 20 mg/mL drop solution (Nifedipin-ratiopharmâ Tropfen), were analysed.

The accuracy and precision of three different doses of enteral nifedipine (5 mg, 1 mg and 0.5 mg) prepared using eight techniques identified in clinical practice were determined using High Performance Liquid Chromatography (HPLC). Stability over two hours of nifedipine solutions 5 mg/ml prepared from tablets and the drop solution was determined using HPLC.

Results Great variation in dose preparation methods was identified. Analysis of eight preparation techniques showed that doses between 50% and 264% of the intended dose were achieved.

For techniques using manipulated tablets only one technique, using split tablets dispersed in an oral syringe, produced an accurate and reproducible dose for 1 mg and 5 mg doses (97.9% [range 96–99.2%] and 94% [range 93.1–95.1%] respectively). For the 0.5 mg dose none of the techniques produced an accurate and reproducible dose.

Techniques using dilution of the imported liquid showed significant deviations and variability from the intended dose, particularly when the internal drop dosing device was used. Use of syringes to measure the dose improved accuracy and …

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