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Maternal pre-pregnancy body mass index explains infant’s weight and BMI at 14 months: results from a multi-ethnic birth cohort study
  1. Ilse Mesman (ilsemesman{at}
  1. Academic Medical Centre Amsterdam, Netherlands
    1. Tessa J Roseboom
    1. Academic Medical Centre Amsterdam, Netherlands
      1. Gouke J Bonsel
      1. Academic Medical Centre Amsterdam, Netherlands
        1. Reinoud J B J Gemke
        1. VU University Medical Centre, Netherlands
          1. Marcel F van der Wal
          1. Municipal Health Service Amsterdam, Netherlands
            1. Tanja G Vrijkotte (t.vrijkotte{at}
            1. Academic Medical Centre, Netherlands


              Objective: To investigate the association between (self-reported) maternal pre-pregnancy BMI (pBMI), and child’s weight, height and BMI at age 14 months.

              Design: Prospective multi-ethnic community-based cohort study.

              Setting: Amsterdam, The Netherlands.

              Participants: In total 8266 pregnant women filled out a questionnaire, covering sociodemographic data, obstetric history, lifestyle, dietary habits, and psychosocial factors, 2 weeks after their first antenatal visit. 7730 gave birth to a viable, a term, singleton infant with information on birth weight, gender and pregnancy duration. Growth data were available from 3171 of these children.

              Main outcome measures: Weight (g), height (cm) and BMI (kg/m2) of the child at age 14 months.

              Results: pBMI was linearly associated with weight and BMI of the child at age 14 months. One unit increase in pBMI resulted in an increment of 29 g (95% CI 19-39) in weight and 0.041kg/m2 ( 95% CI 0.030-0.053) in BMI. The effect size decreased after adjustment for birth weight (weight: β19 g, 95% CI 10-28, BMI: β 0.034 kg/m2, 95% CI 0.023-0.046) and hardly changed after adjustment for all other variables (weight: β 21 g, 95% CI 11-30, BMI: β 0.031 kg/m2, 95% CI 0.019-0.043). pBMI was not related to height.

              Conclusions: pBMI is an independent determinant of weight and BMI of the child at age 14 months. At least 1/3 of this effect is mediated through birth weight.

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