Article Text

other Versions

Download PDFPDF
Vitamin K deficiency bleeding: the readiness is all
  1. Paul Clarke (paul.clarke{at}
  1. Norfolk & Norwich University Hospital, United Kingdom
    1. Martin J Shearer (martin.shearer{at}
    1. Centre for Haemostasis & Thrombosis, St Thomas's Hospital, London, UK., United Kingdom


      Over 10 years ago, William Hathaway described the 50-year chequered history of the association between a neonatal bleeding disorder and vitamin K deficiency and its prevention as a splendid example of the cyclical nature of discovery-rediscovery in medical science 1. The lessons that should have been learnt from the extensive body of early work were reiterated in a recent lively review in this Journal 2. In the UK these forgotten lessons first resurfaced in a 1983 Lancet article entitled ‘haemorrhagic disease of the newborn returns’ 3. Of course this rare deficiency syndrome, now more accurately termed vitamin K deficiency bleeding (VKDB), had never gone away but had merely been rediscovered at a time of a progressive trend towards exclusive breast feeding. The latter had long since been established as an important risk factor for neonatal hypoprothrombinaemia 4.

      • Konakion
      • PIVKA-II
      • hemorrhage
      • phytomenadione
      • undercarboxylated prothrombin

      Statistics from

      Request Permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

      Linked Articles