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Using NSAID in volume depleted children can precipitate acute renal failure
  1. Cheri Mathews John (cherijohn25{at}
  1. Royal Liverpool Children's Hospital, United Kingdom
    1. Rajeev Shukla (rajeev.shukla{at}
    1. Royal Liverpool Children's Hospital, United Kingdom
      1. Caroline A Jones (caroline.jones{at}
      1. Royal Liverpool Children's Hospital, United Kingdom


        Non-Steroidal Anti-Inflammatory Drugs (NSAID) are ever increasing in popularity in hospital medicine, general practice and are readily available over the counter. The vast majority of healthy children who ingest therapeutic doses of NSAID for a limited duration tolerate them without any significant adverse effects. The risk of renal toxicity is potentially increased in situations where there is a stimulation of the renin-angiotensin system such as volume depletion or pre-existing chronic renal disease. We describe four cases which illustrate this complication occurring in a children’s hospital. We have not proven cause and effect but further research is needed to define the true risk of the potential renal complication of NSAID in patients at risk of dehydration.

        • NSAID
        • dehydration
        • intra-vascular volume depletion
        • renal complications

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          BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health