C-Section Births may Represent Low DHEA and the Consequences of Low DHEA
I suggest the explanation of the findings of Huh, et al., involves dehydroepiandrosterone (DHEA). The fetus does not produce significant DHEA until just before birth. Prior to birth, the fetus is dependent upon maternal DHEA. I suggest a combination of maternal and fetal DHEA combine to initiate birth. If insufficient DHEA exists, then caesarean section would be necessary.
Low DHEA is connected with obesity. Therefore, it could be that the mother is low DHEA which could increase weight in the mother and the fetus. Since DHEA is known to protect against all types of infections, the finding that Firmicutes bacteria is increased in children born via caesarean section may indicate low DHEA.
Conflict of Interest: