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G136. CONGENITAL HEART DISEASE IN PREMATURE INFANTS
N. Sabrine, K. Tanner, C. Wren.
Department of Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne
Aims: To assess the prevalence at live birth and spectrum of congenital heart disease in premature infants.
Methods: Ascertainment of all congenital heart disease (CHD) diagnosed in infancy in the resident population of one health region in 1987–2000. All babies with PDA or ASD were excluded to avoid selection bias. All babies with a gestation at birth of <37 weeks were identified. Data from our region and from the literature predict that 5.6% of all babies will be live born at 32–36 weeks, 0.85% at 28–31 weeks, and 0.35% at <28 weeks. Thus 6.8% of live born babies will be pre-term.
Results: Of 492,559 live births in the 14 years of the study, there were 2795 with CHD (excluding PDA and ASD), a prevalence at live birth of 5.7/1000. CHD was present in 5.1/1000 of term babies and 13.4/1000 of pre-term babies. The odds ratio for CHD in prematurity is 2.7 (95% CI 2.1–3.3). 450 of 2795 babies with CHD were born prematurely (16%). The proportion of babies born prematurely was higher with some specific diagnoses, notably pulmonary atresia with VSD (25%), complete AV septal defect (23%), pulmonary stenosis (21%), coarctation of the aorta (20%), and tetralogy of Fallot (19%).
Conclusions: There is a greater than two-fold excess of congenital heart disease in pre-term compared with term babies. 16% of all babies with CHD are pre-term. This excess is more marked for specific malformations, particularly pulmonary atresia with VSD and complete AV septal defect.
G137. PREVALENCE OF COMPONENTS OF THE INSULIN RESISTANCE SYNDROME (IRS) IN A MULTI-RACIAL SAMPLE OF OBESE CHILDREN AND ADOLESCENTS
R.M. Viner, E. Lichtarowicz-Krynska, T.Y. Segal, P. Hindmarsh.
London Centre for Paediatric Endocrinology & Metabolism, University College London
Aims: The insulin resistance syndrome (IRS) is strongly predictive of increased risk of diabetes and cardiovascular disease in adults. Components of the IRS …