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Interferon α treatment of molluscum contagiosum in immunodeficiency
  1. Jonathan Hourihanea,
  2. Elizabeth Hodgesb,
  3. John Smithb,
  4. Martin Keefec,
  5. Alison Jonesd,
  6. Gary Connette
  1. aChild Health, University of Southampton, Southampton University Hospitals NHS Trust, Southampton SO16 6YO, UK, bWessex Immunology Laboratory, Southampton University Hospitals NHS Trust, cDermatology, Royal South Hants Hospital, Southampton SO14 0YG, UK, dImmunology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK, eChild Health, Southampton University Hospitals NHS Trust
  1. Dr J Hourihane, Immunobiology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK

Abstract

A sister (aged 6 years) and brother (aged 8 years) presented four months apart with severe molluscum contagiosum. Both children demonstrated clinical and laboratory evidence of combined immunodeficiency. The extent of skin involvement by molluscum contagiosum precluded conventional treatment as well as intralesional interferon α (IFNα). Both subjects responded well to subcutaneous IFNα.

  • immunodeficiency
  • molluscum contagiosum
  • interferon α

https://doi.org/10.1136/adc.80.1.77

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