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Primary Paediatrics
O-190 Vitamin C And E With Some Inflammatory Cytokines In Children Versus Adolescents With Atopic Dermatities
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  1. E Abdel Hamid1,
  2. H Ahmed2,
  3. R Sabry1,
  4. I Kamel1,
  5. H Ali3
  1. 1Child Health Departement, National Research Center, Cairo, Egypt
  2. 2Hormon Departement, National Research Center, Cairo, Egypt
  3. 3Theraputic Chemistry Departement, National Research Center, Cairo, Egypt

Abstract

Atopic dermatitis (AD), is a chronic inflammatory skin disease. It has two phases, acute and chronic. Studies pointed to interleukin (IL)-18 as key player in the pathogenesis of AD and the switch between its two phases.

Objective This study is designed to evaluate serum IL-18 among other T helper (Th) cytokines IL-4, IL-10, IL-12, interferon- γ (IFN-γ), tumour necrosis factor – α (TNF –α) and immunoglobulin E (Ig E), in addition to vitamins E and C in children and adolescents with acute and chronic AD.

Materials and subjects Sixty AD patients were classified into two main groups; children (acute) and adolescents (chronic) AD of thirty each. In addition, two corresponding healthy normal control groups of thirty each were considered. Serum IL-4, IL-10, IL-12, IL-18, IFN-γ and IgE were estimated by ELISA.

Results IL-12, IL-18 and IFN-γ levels were 2–4 folds more in chronic AD compared to normal subjects. While, IL-18 showed significant higher mean value in chronic than acute AD patients. Although, TNF –α showed, significant increase one fold and half in acute than chronic AD. Moreover, vitamins C and E showed significant decrease in both cases with severe reduction in chronic than acute AD patients.

Conclusion ILs, IFN-γ, TNF- α and serum IgE have a pivotal role in AD. IL-18 measurement is a valuable tool for assessment of the difference in age related – disease severity. Intensive reduction in both vitamins C and E in chronic AD patients than acute one.

https://doi.org/10.1136/archdischild-2014-307384.258

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