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PO-1019 Clinical Characteristics And Risk Factors Of Severe Respiratory Syncytial Virus-associated Acute Lower Respiratory Tract Infections In Hospitalised Infants
  1. L Liu,
  2. X Zhang,
  3. L Qian,
  4. L Wang,
  5. Y Yin
  1. Department of Respiratory Medicine, Children’s Hospital of Fudan University, Shanghai, China


Objective To investigate the clinical characteristics and analyse risk factors for severe respiratory syncytial virus (RSV) infection in hospitalised infants with acute lower respiratory tract infections (ALRIs).

Methods A retrospective review of the medical records of infants with RSV-associated ALRIs between March 1st, 2011 and February 29th, 2012 was done.

Results Among 913 RSV-associated ALRI infants, there were 288 severe infants (31.5%). The severe cases accounted for 4.2% of the hospitalised children and gave a hospital RSV mortality rate of 1.0%. The occurrence of severe RSV infection had a seasonal variation, with a peak in winter (45.6%). The proportions of cases with tachypnea, apnea, cyanosis, and fine rales were significantly higher in the severe ALRIs group (all p < 0.001). The incidences of bronchitis, pneumonia and readmission in the severe group were higher than those in the non-severe infants during the one-year follow-up (all p < 0.001). Multivariate logistic regression determined the factors increasing the risk of severe RSV infection were: low-birth-weight [1.698 (1.028~2.805)], under 3 months of age [3.385 (2.174~5.271)], congenital heart disease [1.667 (1.149~2.418)], bronchopulmonary dysplasia [8.505 (1.731~41.780)], and airway abnormalities [2.246 (1.008~5.005)].

Conclusions Severe RSV infection is associated with a high hospitalisation and mortality. Preventative measures should be targeted against high-risk hospitalised infants, especially those who are low-birth-weight, under 3 months of age, and with underlying diseases.

  • Respiratory syncytial virus
  • Acute lower respiratory tract infections
  • Risk factor

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