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Neuromuscular Disorders
O-073 Total And Regional Corpus Callosum Volumes Are Related To Intelligence And Motor Function In Dyskinetic Cerebral Palsy
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  1. J Ballester-Plané1,
  2. O Laporta-Hoyos1,
  3. A Macaya2,
  4. P Póo3,
  5. M Meléndez4,
  6. E Vázquez5,
  7. I Delgado5,
  8. A Narberhaus1,
  9. T Castelló4,
  10. ME Russi3,
  11. V Tenorio6,
  12. L Zubiaurre-Elorza7,
  13. C Torroja-Nualart8,
  14. D Segarra1,
  15. R Pueyo1
  1. 1Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
  2. 2Paediatric Neurology, Hospital Vall d’Hebron, Barcelona, Spain
  3. 3Neurology, Hospital Sant Joan de Déu, Barcelona, Spain
  4. 4Physical Medicine and Rehabilitation, Hospital Vall d’Hebron, Barcelona, Spain
  5. 5Radiology, Hospital Vall d’Hebron, Barcelona, Spain
  6. 6Institute Clinic of Gynecology Obstetrics and Neonatology, Hospital Clínic de Barcelona, Barcelona, Spain
  7. 7The Brain and Mind Institute, Western University, Ontario, Canada
  8. 8Methodology and Behavioral Sciences, University of Barcelona, Barcelona, Spain

Abstract

Background The relationship between corpus callosum (CC) morphology and mainly motor outcomes has been studied in spastic cerebral palsy (CP) but not yet in dyskinetic CP, which has been recently related to a diffuse brain injury pattern. This study aims to analyse the relationship of total and regional CC volumes with intelligence and motor impairment severity in dyskinetic CP.

Methods 15 subjects (age range, 12–34) with dyskinetic CP and signs of perinatal asphyxia underwent a MRI. CC total, anterior, central and posterior volumes were calculated (Figure 1). The intelligence and motor scales most commonly used in CP were administered.

Abstract O-073 Figure 1
Abstract O-073 Figure 1

CC subdivisions generated by Freesurfer (in colour)

Results The CC total volume and most of its parts were related to intelligence and motor measures (Table 1).

View this table:
Abstract O-073 Table 1

Partial correlation controlling for age

Conclusions Total CC volume may be indicative of intelligence and motor status in dyskinetic CP. Regionally, the posterior part is the most related to intelligence, in agreement with recent theories of intelligence. The anterior part of the CC is not found to be related to motor function. This result agrees with the fact that premotor and sensorimotor fibres are located more posteriorly than previously thought.

https://doi.org/10.1136/archdischild-2014-307384.142

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