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Metabolism
O-050 The Role Of Fto Rs17817449 And Rs 9939609 Snp (single Nucleotide Polymorphism) In Children’ Obesity
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  1. O Marginean1,
  2. C Banescu2,
  3. M Marginean3,
  4. F Tripon3,
  5. G Crauciuc3
  1. 1Pediatrics, University of Medicine and Pharmacy, Tirgu Mures, Romania
  2. 2Genetics, University of Medicine and Pharmacy, Tirgu Mures, Romania
  3. 3Medicine, University of Medicine and Pharmacy, Tirgu Mures, Romania

Abstract

Obesity is a problem with great importance and certain actuality in the field of paediatric pathology because of its increased incidence in children and its complications. Fat mass and obesity associated (FTO) genes are related with weight gain and obesity during childhood, being correlated with body mass index (BMI) and leptin levels.

The aim of our study was to establish the role of the polymorphisms of rs9939609 and rs17817449 FTO genes in determining obesity in a child population from Romania.

Methods We assessed 225 hospitalised children in a tertiary emergency paediatric hospital divided into: control group - 110 patients with normal nutritional status and obese group -105 patients. The two groups underwent the evaluation of FTO rs17817449 and rs 9939609 SNP, and the measurement of anthropometric parameters [body mass index (BMI), middle upper arm circumference (MUAC), tricipital skinfold thickness (TST)].

Results We observed that the AA genotype of Rs9939609 SNP gene, is more frequent in obese group [p = 0.01, OR 2.778 95% CI (1.245–6.201)] and the A alleles is heigher in obese group [p = 0, 0148, OR 1,692 95%]. According to the RS17817449 gene mutation no association was found. We observed correlations in AA genotype, between BMI and MUAC (p = 0.0011) and TST, while A allele carriers was associated only with MUAC.

Conclusion Rs9939609 SNP AA genotype and A allele carriers are associated with obesity in children, and are both correlated with BMI and MUAC, while AA genotype is also correlated with TST.

https://doi.org/10.1136/archdischild-2014-307384.118

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