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PO-0486 Cerebral Haemodynamic Response To Blood Transfusion Varies With Chronological Age In Preterm Infants
  1. J Banerjee1,
  2. TS Leung2,
  3. N Aladangady1
  1. 1Department of Neonatology, Homerton University Hospital, London, UK
  2. 2Department of Medical Physics and Bioengineering, University College London, London, UK


Background and aims We have shown that cerebral blood flow decreases following blood transfusion (BT) in extreme preterm infants during the first week of life.1

Aim To investigate the cerebral blood flow changes following BT in relation to the chronological age of preterm infants.

Methods Preterm infants who received BT during the first 10 weeks of life were included. Pre and post-BT Anterior Cerebral artery (ACA) mean velocity, resistance index (RI) and pulsatility index (PI), and Superior Vena Cava (SVC) flow were measured using Doppler USS. Pre and post BT measurements were compared by paired t-test using SPSS 22.0.

Results 59 BT events were studied, 20 received BT during 1st week (Group 1), 21 during the 2nd to 4th week (Group 2) and 18 during >4th week (Group 3) of age. The median age (range) at BT was 5 (1–7), 14 (8–27) and 45 (29–68) days for group 1, 2 and 3 respectively. In all 3 groups the pre-BT ACA mean velocity decreased significantly post-BT (p < 0.03) and there was no significant change in RI and PI in the ACA. The pre-BT mean SVC flow decreased significantly post-BT in Group 1 and Group 3 (p = 0.03 and <0.001 respectively), but this was not significant in the Group 2 infants (p = 0.16).

Conclusion The effect of BT on cerebral haemodynamics was more prominent during the first week and after 4th week of age in preterm infants.

Reference 1 Banerjee J et al. PAS Conference May 2014

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