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PO-0403 Usefulness Of The Evaluation Of Cerebral Blood Volume To Predict Adverse Outcomes In Infants With Asphyxia
  1. A Hirose1,
  2. A Kondo1,
  3. T Takami2,
  4. D Sunohara1,
  5. H Kawashima1
  1. 1Pediatrics, Tokyo Medical University, Tokyo, Japan
  2. 2Neonatology, Toho University, Tokyo, Japan


Background and aims Increased cerebral haemoglobin oxygen saturation (rSO2) and decreased cerebral fractional tissue oxygen extraction (FTOE) 24 h after birth in infants have reported to be associated with adverse outcomes. Near-infraredtime-resolved spectroscopy (TRS) device enables the simultaneous assessment of quantitative hemodynamics, and absolute values of (rSO2) and cerebral bloodvolume (CBV). The purpose of our study was to determine the usefulness of both rSO2 and CBV measured by TRS in infants with asphyxia after birth.

Methods Twenty-six infants with asphyxia (Apgar score < 7 at 1 min after birth) were divided into 2 groups: those with hypoxic-ischaemic encephalopathy (HIE; HIE group, n = 5) and those without hypoxic-ischaemic encephalopathy (non-HIE group, n = 21). rSO2 and FTOE were measured by TRS at 12, 24, 48, and 72 h after birth.

Results rSO2 was significantly higher and FTOE was significantly lower in the HIE group (n = 5) than in the non-HIE group (n = 21) at 12, 24, 48, and 72 h after birth. CBV was significantly higher in the HIE group (n = 5) than in the non-HIE (n = 21) from 3–6 h after birth through all measurement time points.

Conclusions Changes in CBV occurred earlier than those in rSO2. Thus, CBV may be an early predictive parameterfor adverse outcomes in infants with asphyxia after birth.

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