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PO-0389 Outcome Of Very Preterm Children At School Age: Results From The Area-based Italian Action Follow-up Study
  1. M Cuttini1,
  2. M Lacchei1,
  3. G Riccio1,
  4. C Giorno1,
  5. C Rosa1,
  6. C Melon2,
  7. M Carrozzi2,
  8. P Brovedani3,
  9. V Chiandotto4,
  10. E Pessina4,
  11. N Bressan4,
  12. V Svelto5,
  13. F Voller5
  1. 1Research Unit of Perinatal Epidemiology, Pediatric Hospital Bambino Gesu, Roma, Italy
  2. 2Department of Neuroscience, Burlo Garofolo Hospital, Trieste, Italy
  3. 3Neonatal Intensive Care Unit, Burlo Garofolo Hospital, Trieste, Italy
  4. 4Neonatal Intensive Care Unit, S. Maria Della Misericordia Hospital, Udine, Italy
  5. 5Osservatorio Di Epidemiologia, Agenzia Di Sanità Della Toscana, Firenze, Italy


Background and aims Children born before 32 weeks of gestational age (GA) have increased risk of neurological, sensory, cognitive and behavioural problems. The latter become evident at school age, but follow-up is rarely continued up to this time. We present preliminary results of ongoing follow-up at school age of the Italian ACTION area-based cohort.

Methods All infants born <32 weeks GA in 2003–2004 in three regions (Lazio, Tuscany and Friuli Venezia-Giulia) and survived to school-age were invited. The Kaufman Assessment Battery second edition (KABC-II) and selected items of NEPSY-II were used to assess cognitive and neuropsychological development. Only results for Lazio and Trieste area in FVG, where follow-up is already completed, are included (n 390, response rate 58%).

Results Fifty-six percent of children (n 218) were males; 35% (1379 were ≤28 weeks GA. About 8% (n 30) had cerebral palsy; six children (1.5%) were blind or almost blind, and 12 (3.1%) required hearing aids. Twenty-two percent of children had KABC-II Mental Development Index (MPI) below average (29.9% in children born ≤28 weeks gestation, p = 0.008). Lower MPI scores were associated with impaired neuropsychological abilities.

Conclusions While most children have cognitive level within normal range, lower KABC-II and NEPSY-II scores were found particularly in the more preterm group. Sensorimotor abilities were the most frequently compromised neuropsychological functions.

Acknowledgements The ACTION follow-up project was funded by the Italian Ministry of Health and by the Chiesi Farmaceutici S.p. A.

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