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O-021 Prevention Of Bronchopulmonary Dysplasia (bpd) In Vlbw Infants With Severe Rds – A Randomised Trial Of A New Therapeutic Regimen
  1. TF Yeh1,
  2. SY Wu2,
  3. Z Ullah2,
  4. TC Li3,
  5. WS Hsieh4,
  6. CH Tsai5,
  7. HC Lin5,
  8. CM Chen6
  1. 1Mat. Child Health Center, Taipei Medical University, Taipei, Taiwan
  2. 2Department of Pediatrtics, John Stroger Hospital of Cook County, Chicago, USA
  3. 3Graduate Institute of Biostatistics, China Medical University, Taichung, Taiwan
  4. 4Department of Pediatrics, National Taiwan University, Taipei, Taiwan
  5. 5Department of Pediatrics, China Medical University, Taichung, Taiwan
  6. 6Department of Pediatrtics, Taipei Medical University Hospital, Taipei, Taiwan


Background/aims Intra-tracheal instillation of surfactant/budesonide significantly improves pulmonary status in animals. The aim is to investigate if this therapy would decrease the incidence of BPD or death.

Methods and materials This randomised controlled trial comprised 265 VLBW infants who had: 1) severe radiographic RDS, 2) requirement of IMV (FIO2 ≥ 0.5) shortly after birth: 131 received survanta (S) (100 mg/kg) and budesonide (B) (0.25 mg/kg) (S+B gr.), 134 received S only (100 mg/kg) (S gr). The sample size was determined based on the hypothesis that 60% of infants in the S group and 40% in the S+B group would die or develop BPD defined at 34 weeks postm. age.

Abstract O-021 Table 1

ResultsThe S+B infant had lower tracheal aspirate interleukins 1, 6 and 8, lower OI, lower MAP in the early course of therapy, higher chance to wean to room air (p = 0.03). No significant immediate and long term adverse effects were observed. * NIH criteria

Conclusions In VLBW infants with severe RDS, administration of surfactant/budesonide significantly decreases the incidence of BPD and BPD or death with no apparent adverse side effects.

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