Background and aims Intestinal colic in the infants is often found in early childhood and is one of the most frequent causes of complaints of parents to the paediatrician. They have functional genesis in 90% of cases, and terminated without treatment at the age of 3–4 months. Problem of Colic needs further study of the causes of disease and the possibility of its correction.

Methods We inspected of 66 children (aged from 6 to 66 days, M±m, 33,52 ± 3,85 days) which have primary diagnosis colic on the bases of Clinical Children Hospital, uzhgorod, Ukraine.

Results The investigation contingent have follows assotiation diagnosis: Acute Respiratory Viral Infection (18,18 ± 4,78%), Pyelonephritis (6,06 ± 2,46%), Pneumonia (9,09 ± 3,57%) Syndrome increased neur-reflex excitability (10,61 ± 3,82%), Protein-energy malnutrition (13,64 ± 4,26%), Atopic dermatitis (9,09 ± 3,57%), Matabolic syndrome (3,03 ± 2,13%), Anaemia (3,03 ± 2,13%), Bullous dermatitis (4,55 ± 2,58%), Jaundice (4,55 ± 2,58), Torticollis (3,03 ± 2,13%), Perinatal infection (3,03 ± 2,13%). Body weight at the birth was 3214,50 ± 84,57 h, at the time of inspection - 3785,24 ± 151,94 h, (n = 66). Clinical signs in the children: Anxiety (100%), Sharp cry (6,06 ± 2,46%), Weakness (10,61 ± 3,82%), Frequent regurgitation (89,39 ± 3,82%), Periodical Vomiting (6,06 ± 2,46), Flatulence (100), High. Temperature (3,03 ± 2,13) Vomiting (4,55 ± 2,58), The rejection of breastfeeding (3,03 ± 2,13), Obstacle breathing (18,18 ± 4,78), Diarrhoea (3,03 ± 2,13).

Conclusions The colic diagnosed in the children with assotiation pathology-acute respiratory viral infection, syndrome increased neur-reflex excitability, protein-energy malnutrition. Intestinal colic were characterised by of Anxiety, Flatulence, Frequent regurgitation, Weakness, Obstacle breathing for our dates. The dominant factors in the development of colic are inflammation and nutritional desorder in the clinical design.