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Nephrology
PS-235 The Effects Of Response Gene To Complement 32 As A New Biomarker In Children With Acute Kidney Injury
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  1. HJ Liu1,
  2. YL Shen1,
  3. L Sun1,
  4. XY Kuang1,
  5. RF Zhang2,
  6. H Zhang3,
  7. XB Li2,
  8. WY Huang1
  1. 1Nephrology and Rheumatology, Shanghai Children’s Hospital Shanghai Jiaotong University, Shanghai, China
  2. 2Cardiothoracic Surgery, Shanghai Children’s Hospital Shanghai Jiaotong University, Shanghai, China
  3. 3Clinical Laboratories, Shanghai Children’s Hospital Shanghai Jiaotong University, Shanghai, China

Abstract

Background and aims To investigate the new biomarkers of acute kidney injury, as well as to conform the values of response gene to complement-32 (RGC-32) protein for early diagnosis of acute kidney injury in children who had undergone cardiopulmonary bypass (CPB).

Methods 67 patients accepted CPB assigned to acute kidneyinjury group (AKI group) or non-acute kidney injury group (non-AKI group). Serum samples were taken regularly after CPB 30 min, 2 h, 4 h, 24 h, 48 h and 72 h for serumRGC-32, creatinine (Scr) and Cystatin C (CysC) measurement.

Results The incidence of AKI was 34%, including 15 cases with Risk stage AKI, 4 cases with Injury stage AKI, 3 cases with Failure stage AKI, 1 cases with Loss stage AKI. The values for sensitivity of serum RGC-32 after CPB 30 min, 2 h and 4 h as 0.914, 0.824, 0.824 and the values for specificity of serum RGC-32 as 0.619, 0.667, 0.810, respectively.

Conclusion In this study, our results first identify that possibly the sensitivity of serum RGC-32 for detecting AKI are much higher than that of Scr and serum CysC in children who had accepted CPB, and that RGC-32 may be a new biomarker for early detection of AKI. However, the conclusion needs to be further elucidated.

https://doi.org/10.1136/archdischild-2014-307384.534

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