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How nice it would be if a single, well-tolerated drug could treat simple obesity. Metformin, originally developed to treat type 2 diabetes, has been used for some years in overweight children in the hope that its well-recognised metabolic effects will reduce fat deposition. Researchers from the US, where the prevalence of childhood obesity is higher than anywhere, conducted a systematic review (McDonagh et al. JAMA Pediatr online doi:10.1001/jamapediatrics.2013.4200). They identified 14 randomised controlled trials (RCTs) of sufficient …
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